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Physical activity and total serum bilirubin levels among insulin sensitive and insulin resistant U.S. adults

BACKGROUND: Total serum bilirubin has been identified as a novel biomarker for metabolic disease, with higher levels providing protection against metabolic disease. To our knowledge, only 3 studies, to date, have examined the association between physical activity and total serum bilirubin, with thes...

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Autores principales: Loprinzi, Paul D, Abbott, Kalen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000149/
https://www.ncbi.nlm.nih.gov/pubmed/24708607
http://dx.doi.org/10.1186/2251-6581-13-47
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author Loprinzi, Paul D
Abbott, Kalen
author_facet Loprinzi, Paul D
Abbott, Kalen
author_sort Loprinzi, Paul D
collection PubMed
description BACKGROUND: Total serum bilirubin has been identified as a novel biomarker for metabolic disease, with higher levels providing protection against metabolic disease. To our knowledge, only 3 studies, to date, have examined the association between physical activity and total serum bilirubin, with these studies reporting mixed findings. One potential reason for the mixed findings may be the exclusive use of self-report physical activity methodology. The purpose of this study was to examine the association between accelerometer-assessed physical activity and total serum bilirubin among a national sample of U.S. insulin sensitive and insulin resistant adults. METHODS: Data from the 2003-2006 National Health and Nutrition Examination Survey were used. Physical activity was objectively-measured using an accelerometer over a 7 day period. Bilirubin levels were assessed from a blood sample. Data was analyzed in 2013. RESULTS: After adjusting for age, gender, race-ethnicity, BMI, comorbid illness, cotinine, and poverty level, moderate-to-vigorous physical activity (MVPA) was associated with bilirubin for insulin resistant individuals (β = 0.08; p = 0.04), but not insulin sensitive individuals (β = 0.02; p = 0.38). CONCLUSIONS: MVPA is associated with total serum bilirubin levels among U.S. adults with insulin resistance. Future experimental and prospective studies are needed, with further attention focused on the mechanisms that may help to explain the association between physical activity and bilirubin.
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spelling pubmed-40001492014-04-26 Physical activity and total serum bilirubin levels among insulin sensitive and insulin resistant U.S. adults Loprinzi, Paul D Abbott, Kalen J Diabetes Metab Disord Research Article BACKGROUND: Total serum bilirubin has been identified as a novel biomarker for metabolic disease, with higher levels providing protection against metabolic disease. To our knowledge, only 3 studies, to date, have examined the association between physical activity and total serum bilirubin, with these studies reporting mixed findings. One potential reason for the mixed findings may be the exclusive use of self-report physical activity methodology. The purpose of this study was to examine the association between accelerometer-assessed physical activity and total serum bilirubin among a national sample of U.S. insulin sensitive and insulin resistant adults. METHODS: Data from the 2003-2006 National Health and Nutrition Examination Survey were used. Physical activity was objectively-measured using an accelerometer over a 7 day period. Bilirubin levels were assessed from a blood sample. Data was analyzed in 2013. RESULTS: After adjusting for age, gender, race-ethnicity, BMI, comorbid illness, cotinine, and poverty level, moderate-to-vigorous physical activity (MVPA) was associated with bilirubin for insulin resistant individuals (β = 0.08; p = 0.04), but not insulin sensitive individuals (β = 0.02; p = 0.38). CONCLUSIONS: MVPA is associated with total serum bilirubin levels among U.S. adults with insulin resistance. Future experimental and prospective studies are needed, with further attention focused on the mechanisms that may help to explain the association between physical activity and bilirubin. BioMed Central 2014-04-07 /pmc/articles/PMC4000149/ /pubmed/24708607 http://dx.doi.org/10.1186/2251-6581-13-47 Text en Copyright © 2014 Loprinzi and Abbott; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Loprinzi, Paul D
Abbott, Kalen
Physical activity and total serum bilirubin levels among insulin sensitive and insulin resistant U.S. adults
title Physical activity and total serum bilirubin levels among insulin sensitive and insulin resistant U.S. adults
title_full Physical activity and total serum bilirubin levels among insulin sensitive and insulin resistant U.S. adults
title_fullStr Physical activity and total serum bilirubin levels among insulin sensitive and insulin resistant U.S. adults
title_full_unstemmed Physical activity and total serum bilirubin levels among insulin sensitive and insulin resistant U.S. adults
title_short Physical activity and total serum bilirubin levels among insulin sensitive and insulin resistant U.S. adults
title_sort physical activity and total serum bilirubin levels among insulin sensitive and insulin resistant u.s. adults
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000149/
https://www.ncbi.nlm.nih.gov/pubmed/24708607
http://dx.doi.org/10.1186/2251-6581-13-47
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