Cargando…
Physical activity and total serum bilirubin levels among insulin sensitive and insulin resistant U.S. adults
BACKGROUND: Total serum bilirubin has been identified as a novel biomarker for metabolic disease, with higher levels providing protection against metabolic disease. To our knowledge, only 3 studies, to date, have examined the association between physical activity and total serum bilirubin, with thes...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000149/ https://www.ncbi.nlm.nih.gov/pubmed/24708607 http://dx.doi.org/10.1186/2251-6581-13-47 |
_version_ | 1782313585956880384 |
---|---|
author | Loprinzi, Paul D Abbott, Kalen |
author_facet | Loprinzi, Paul D Abbott, Kalen |
author_sort | Loprinzi, Paul D |
collection | PubMed |
description | BACKGROUND: Total serum bilirubin has been identified as a novel biomarker for metabolic disease, with higher levels providing protection against metabolic disease. To our knowledge, only 3 studies, to date, have examined the association between physical activity and total serum bilirubin, with these studies reporting mixed findings. One potential reason for the mixed findings may be the exclusive use of self-report physical activity methodology. The purpose of this study was to examine the association between accelerometer-assessed physical activity and total serum bilirubin among a national sample of U.S. insulin sensitive and insulin resistant adults. METHODS: Data from the 2003-2006 National Health and Nutrition Examination Survey were used. Physical activity was objectively-measured using an accelerometer over a 7 day period. Bilirubin levels were assessed from a blood sample. Data was analyzed in 2013. RESULTS: After adjusting for age, gender, race-ethnicity, BMI, comorbid illness, cotinine, and poverty level, moderate-to-vigorous physical activity (MVPA) was associated with bilirubin for insulin resistant individuals (β = 0.08; p = 0.04), but not insulin sensitive individuals (β = 0.02; p = 0.38). CONCLUSIONS: MVPA is associated with total serum bilirubin levels among U.S. adults with insulin resistance. Future experimental and prospective studies are needed, with further attention focused on the mechanisms that may help to explain the association between physical activity and bilirubin. |
format | Online Article Text |
id | pubmed-4000149 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-40001492014-04-26 Physical activity and total serum bilirubin levels among insulin sensitive and insulin resistant U.S. adults Loprinzi, Paul D Abbott, Kalen J Diabetes Metab Disord Research Article BACKGROUND: Total serum bilirubin has been identified as a novel biomarker for metabolic disease, with higher levels providing protection against metabolic disease. To our knowledge, only 3 studies, to date, have examined the association between physical activity and total serum bilirubin, with these studies reporting mixed findings. One potential reason for the mixed findings may be the exclusive use of self-report physical activity methodology. The purpose of this study was to examine the association between accelerometer-assessed physical activity and total serum bilirubin among a national sample of U.S. insulin sensitive and insulin resistant adults. METHODS: Data from the 2003-2006 National Health and Nutrition Examination Survey were used. Physical activity was objectively-measured using an accelerometer over a 7 day period. Bilirubin levels were assessed from a blood sample. Data was analyzed in 2013. RESULTS: After adjusting for age, gender, race-ethnicity, BMI, comorbid illness, cotinine, and poverty level, moderate-to-vigorous physical activity (MVPA) was associated with bilirubin for insulin resistant individuals (β = 0.08; p = 0.04), but not insulin sensitive individuals (β = 0.02; p = 0.38). CONCLUSIONS: MVPA is associated with total serum bilirubin levels among U.S. adults with insulin resistance. Future experimental and prospective studies are needed, with further attention focused on the mechanisms that may help to explain the association between physical activity and bilirubin. BioMed Central 2014-04-07 /pmc/articles/PMC4000149/ /pubmed/24708607 http://dx.doi.org/10.1186/2251-6581-13-47 Text en Copyright © 2014 Loprinzi and Abbott; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Loprinzi, Paul D Abbott, Kalen Physical activity and total serum bilirubin levels among insulin sensitive and insulin resistant U.S. adults |
title | Physical activity and total serum bilirubin levels among insulin sensitive and insulin resistant U.S. adults |
title_full | Physical activity and total serum bilirubin levels among insulin sensitive and insulin resistant U.S. adults |
title_fullStr | Physical activity and total serum bilirubin levels among insulin sensitive and insulin resistant U.S. adults |
title_full_unstemmed | Physical activity and total serum bilirubin levels among insulin sensitive and insulin resistant U.S. adults |
title_short | Physical activity and total serum bilirubin levels among insulin sensitive and insulin resistant U.S. adults |
title_sort | physical activity and total serum bilirubin levels among insulin sensitive and insulin resistant u.s. adults |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000149/ https://www.ncbi.nlm.nih.gov/pubmed/24708607 http://dx.doi.org/10.1186/2251-6581-13-47 |
work_keys_str_mv | AT loprinzipauld physicalactivityandtotalserumbilirubinlevelsamonginsulinsensitiveandinsulinresistantusadults AT abbottkalen physicalactivityandtotalserumbilirubinlevelsamonginsulinsensitiveandinsulinresistantusadults |