Conformational Dynamics of DNA G-Quadruplex in Solution Studied by Kinetic Capillary Electrophoresis Coupled On-line with Mass Spectrometry

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Invited for this months cover is the group of Prof. Maxim V. Berezovski. The cover picture shows the two-dimensional separation of unfolded (green) and folded (red) forms of G-quadruplex (GQ) DNA. The first dimension is kinetic capillary electrophoresis (KCE) separation of unfolded and folded DNA wi...

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Detalles Bibliográficos
Autor principal: Berezovski, Maxim V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley-VCH Verlag GmbH & Co 2014
Materias:
Cover Profiles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000165/
https://www.ncbi.nlm.nih.gov/pubmed/24808989
http://dx.doi.org/10.1002/open.201400004
Descripción
Sumario:Invited for this months cover is the group of Prof. Maxim V. Berezovski. The cover picture shows the two-dimensional separation of unfolded (green) and folded (red) forms of G-quadruplex (GQ) DNA. The first dimension is kinetic capillary electrophoresis (KCE) separation of unfolded and folded DNA with different K(+) concentrations in solution; the second dimension is ion mobility mass spectrometry separation of DNA conformers in the gas phase. DNA folding into a compact GQ structure is mediated by K(+) ions. For more details, see the Full Paper on p. 58 ff.

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