Cargando…

Clinical utility of circulating tumor cell counting through CellSearch(®): the dilemma of a concept suspended in Limbo

To date, 10 years after the first demonstration of circulating tumor cells (CTCs), prognostic significance in metastatic breast cancer using the US Food and Drug Administration–cleared system CellSearch(®), the potential utility of CTCs in early clinical development of drugs, their role as a surroga...

Descripción completa

Detalles Bibliográficos
Autores principales: Raimondi, Cristina, Gradilone, Angela, Naso, Giuseppe, Cortesi, Enrico, Gazzaniga, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000244/
https://www.ncbi.nlm.nih.gov/pubmed/24790460
http://dx.doi.org/10.2147/OTT.S46200
_version_ 1782313603064397824
author Raimondi, Cristina
Gradilone, Angela
Naso, Giuseppe
Cortesi, Enrico
Gazzaniga, Paola
author_facet Raimondi, Cristina
Gradilone, Angela
Naso, Giuseppe
Cortesi, Enrico
Gazzaniga, Paola
author_sort Raimondi, Cristina
collection PubMed
description To date, 10 years after the first demonstration of circulating tumor cells (CTCs), prognostic significance in metastatic breast cancer using the US Food and Drug Administration–cleared system CellSearch(®), the potential utility of CTCs in early clinical development of drugs, their role as a surrogate marker of response to therapy, and their molecular analysis for patient stratification for targeted therapies are still major unsolved questions. Great expectations are pinned on the ongoing interventional trials aimed to demonstrate that CTCs might be of value for guiding treatment of patients and predicting cancer progression. To fill the gap between theory and practice with regard to the clinical utility of CTCs, a bridge is needed, taking into account innovative design for clinical trials, a revised definition of traditional CTCs, next-generation CTC technology, the potential clinical application of CTC analysis in non-validated settings of disease, and finally, expanding the number of patients enrolled in the studies. In this regard, the results of the first European pooled analysis definitely validated the independent prognostic value of CTC counting in metastatic breast cancer patients.
format Online
Article
Text
id pubmed-4000244
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-40002442014-04-30 Clinical utility of circulating tumor cell counting through CellSearch(®): the dilemma of a concept suspended in Limbo Raimondi, Cristina Gradilone, Angela Naso, Giuseppe Cortesi, Enrico Gazzaniga, Paola Onco Targets Ther Review To date, 10 years after the first demonstration of circulating tumor cells (CTCs), prognostic significance in metastatic breast cancer using the US Food and Drug Administration–cleared system CellSearch(®), the potential utility of CTCs in early clinical development of drugs, their role as a surrogate marker of response to therapy, and their molecular analysis for patient stratification for targeted therapies are still major unsolved questions. Great expectations are pinned on the ongoing interventional trials aimed to demonstrate that CTCs might be of value for guiding treatment of patients and predicting cancer progression. To fill the gap between theory and practice with regard to the clinical utility of CTCs, a bridge is needed, taking into account innovative design for clinical trials, a revised definition of traditional CTCs, next-generation CTC technology, the potential clinical application of CTC analysis in non-validated settings of disease, and finally, expanding the number of patients enrolled in the studies. In this regard, the results of the first European pooled analysis definitely validated the independent prognostic value of CTC counting in metastatic breast cancer patients. Dove Medical Press 2014-04-17 /pmc/articles/PMC4000244/ /pubmed/24790460 http://dx.doi.org/10.2147/OTT.S46200 Text en © 2014 Raimondi et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Raimondi, Cristina
Gradilone, Angela
Naso, Giuseppe
Cortesi, Enrico
Gazzaniga, Paola
Clinical utility of circulating tumor cell counting through CellSearch(®): the dilemma of a concept suspended in Limbo
title Clinical utility of circulating tumor cell counting through CellSearch(®): the dilemma of a concept suspended in Limbo
title_full Clinical utility of circulating tumor cell counting through CellSearch(®): the dilemma of a concept suspended in Limbo
title_fullStr Clinical utility of circulating tumor cell counting through CellSearch(®): the dilemma of a concept suspended in Limbo
title_full_unstemmed Clinical utility of circulating tumor cell counting through CellSearch(®): the dilemma of a concept suspended in Limbo
title_short Clinical utility of circulating tumor cell counting through CellSearch(®): the dilemma of a concept suspended in Limbo
title_sort clinical utility of circulating tumor cell counting through cellsearch(®): the dilemma of a concept suspended in limbo
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000244/
https://www.ncbi.nlm.nih.gov/pubmed/24790460
http://dx.doi.org/10.2147/OTT.S46200
work_keys_str_mv AT raimondicristina clinicalutilityofcirculatingtumorcellcountingthroughcellsearchthedilemmaofaconceptsuspendedinlimbo
AT gradiloneangela clinicalutilityofcirculatingtumorcellcountingthroughcellsearchthedilemmaofaconceptsuspendedinlimbo
AT nasogiuseppe clinicalutilityofcirculatingtumorcellcountingthroughcellsearchthedilemmaofaconceptsuspendedinlimbo
AT cortesienrico clinicalutilityofcirculatingtumorcellcountingthroughcellsearchthedilemmaofaconceptsuspendedinlimbo
AT gazzanigapaola clinicalutilityofcirculatingtumorcellcountingthroughcellsearchthedilemmaofaconceptsuspendedinlimbo