GM-CSF facilitates the development of inflammation-associated colorectal carcinoma

The granulocyte macrophage colony-stimulating factor (GM-CSF) is known to play a protective role in intestinal inflammation. However, the effects of GM-CSF on the progression of colitis to colorectal carcinoma have long remained unclear. We have recently demonstrated that GM-CSF produced by colonic...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Guojiang, Han, Gencheng, Shen, Beifen, Li, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000268/
https://www.ncbi.nlm.nih.gov/pubmed/24778929
http://dx.doi.org/10.4161/onci.28186
Descripción
Sumario:The granulocyte macrophage colony-stimulating factor (GM-CSF) is known to play a protective role in intestinal inflammation. However, the effects of GM-CSF on the progression of colitis to colorectal carcinoma have long remained unclear. We have recently demonstrated that GM-CSF produced by colonic epithelial cells promotes colorectal tumorigenesis by stimulating the secretion of vascular endothelial growth factor.

Ejemplares similares