GM-CSF facilitates the development of inflammation-associated colorectal carcinoma

The granulocyte macrophage colony-stimulating factor (GM-CSF) is known to play a protective role in intestinal inflammation. However, the effects of GM-CSF on the progression of colitis to colorectal carcinoma have long remained unclear. We have recently demonstrated that GM-CSF produced by colonic...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Guojiang, Han, Gencheng, Shen, Beifen, Li, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000268/
https://www.ncbi.nlm.nih.gov/pubmed/24778929
http://dx.doi.org/10.4161/onci.28186
_version_ 1782313606007750656
author Chen, Guojiang
Han, Gencheng
Shen, Beifen
Li, Yan
author_facet Chen, Guojiang
Han, Gencheng
Shen, Beifen
Li, Yan
author_sort Chen, Guojiang
collection PubMed
description The granulocyte macrophage colony-stimulating factor (GM-CSF) is known to play a protective role in intestinal inflammation. However, the effects of GM-CSF on the progression of colitis to colorectal carcinoma have long remained unclear. We have recently demonstrated that GM-CSF produced by colonic epithelial cells promotes colorectal tumorigenesis by stimulating the secretion of vascular endothelial growth factor.
format Online
Article
Text
id pubmed-4000268
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-40002682015-03-07 GM-CSF facilitates the development of inflammation-associated colorectal carcinoma Chen, Guojiang Han, Gencheng Shen, Beifen Li, Yan Oncoimmunology Author's View The granulocyte macrophage colony-stimulating factor (GM-CSF) is known to play a protective role in intestinal inflammation. However, the effects of GM-CSF on the progression of colitis to colorectal carcinoma have long remained unclear. We have recently demonstrated that GM-CSF produced by colonic epithelial cells promotes colorectal tumorigenesis by stimulating the secretion of vascular endothelial growth factor. Landes Bioscience 2014-03-07 /pmc/articles/PMC4000268/ /pubmed/24778929 http://dx.doi.org/10.4161/onci.28186 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Chen, Guojiang
Han, Gencheng
Shen, Beifen
Li, Yan
GM-CSF facilitates the development of inflammation-associated colorectal carcinoma
title GM-CSF facilitates the development of inflammation-associated colorectal carcinoma
title_full GM-CSF facilitates the development of inflammation-associated colorectal carcinoma
title_fullStr GM-CSF facilitates the development of inflammation-associated colorectal carcinoma
title_full_unstemmed GM-CSF facilitates the development of inflammation-associated colorectal carcinoma
title_short GM-CSF facilitates the development of inflammation-associated colorectal carcinoma
title_sort gm-csf facilitates the development of inflammation-associated colorectal carcinoma
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000268/
https://www.ncbi.nlm.nih.gov/pubmed/24778929
http://dx.doi.org/10.4161/onci.28186
work_keys_str_mv AT chenguojiang gmcsffacilitatesthedevelopmentofinflammationassociatedcolorectalcarcinoma
AT hangencheng gmcsffacilitatesthedevelopmentofinflammationassociatedcolorectalcarcinoma
AT shenbeifen gmcsffacilitatesthedevelopmentofinflammationassociatedcolorectalcarcinoma
AT liyan gmcsffacilitatesthedevelopmentofinflammationassociatedcolorectalcarcinoma

Ejemplares similares