Fascin Is Regulated by Slug, Promotes Progression of Pancreatic Cancer in Mice, and Is Associated With Patient Outcomes

BACKGROUND & AIMS: Pancreatic ductal adenocarcinoma (PDAC) is often lethal because it is highly invasive and metastasizes rapidly. The actin-bundling protein fascin has been identified as a biomarker of invasive and advanced PDAC and regulates cell migration and invasion in vitro. We investigate...

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Detalles Bibliográficos
Autores principales: Li, Ang, Morton, Jennifer P., Ma, YaFeng, Karim, Saadia A., Zhou, Yan, Faller, William J., Woodham, Emma F., Morris, Hayley T., Stevenson, Richard P., Juin, Amelie, Jamieson, Nigel B., MacKay, Colin J., Carter, C. Ross, Leung, Hing Y., Yamashiro, Shigeko, Blyth, Karen, Sansom, Owen J., Machesky, Laura M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: W.B. Saunders 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000441/
https://www.ncbi.nlm.nih.gov/pubmed/24462734
http://dx.doi.org/10.1053/j.gastro.2014.01.046

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