Total Synthesis of the Lipid Mediator PD1(n-3 DPA): Configurational Assignments and Anti-inflammatory and Pro-resolving Actions

[Image: see text] The polyunsaturated lipid mediator PD1(n-3 DPA) (5) was recently isolated from self-resolving inflammatory exudates of 5 and human macrophages. Herein, the first total synthesis of PD1(n-3 DPA) (5) is reported in 10 steps and 9% overall yield. These efforts, together with NMR data...

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Detalles Bibliográficos
Autores principales: Aursnes, Marius, Tungen, Jørn E., Vik, Anders, Colas, Romain, Cheng, Chien-Yee C., Dalli, Jesmond, Serhan, Charles N., Hansen, Trond V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000582/
https://www.ncbi.nlm.nih.gov/pubmed/24576195
http://dx.doi.org/10.1021/np4009865

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