Recent Perspectives on APP, Secretases, Endosomal Pathways and How they Influence Alzheimer’s Related Pathological Changes in Down Syndrome

Down syndrome is one of the most common genetic conditions occurring in one in 700 live births. The trisomy of chromosome 21 causes over-expression of APP which in turn is indicated in the increased production of Aβ associated with AD. This makes DS the most common presenile form of AD exceeding PS1...

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Detalles Bibliográficos
Autores principales: DeCourt, Boris, Mobley, William, Reiman, Eric, Shah, Raj Jatin, Sabbagh, Marwan N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000700/
https://www.ncbi.nlm.nih.gov/pubmed/24782952
http://dx.doi.org/10.4172/2161-0460.S7-002
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author DeCourt, Boris
Mobley, William
Reiman, Eric
Shah, Raj Jatin
Sabbagh, Marwan N
author_facet DeCourt, Boris
Mobley, William
Reiman, Eric
Shah, Raj Jatin
Sabbagh, Marwan N
author_sort DeCourt, Boris
collection PubMed
description Down syndrome is one of the most common genetic conditions occurring in one in 700 live births. The trisomy of chromosome 21 causes over-expression of APP which in turn is indicated in the increased production of Aβ associated with AD. This makes DS the most common presenile form of AD exceeding PS1 and PS2 FAD. Since a majority of DS individuals develop dementia, it is important to examine whether DS and sporadic AD share common features, for example, to anticipate shared treatments in the future. Here we explore commonalities and differences for secretases and endosomal pathways in DS and AD.
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spelling pubmed-40007002014-04-27 Recent Perspectives on APP, Secretases, Endosomal Pathways and How they Influence Alzheimer’s Related Pathological Changes in Down Syndrome DeCourt, Boris Mobley, William Reiman, Eric Shah, Raj Jatin Sabbagh, Marwan N J Alzheimers Dis Parkinsonism Article Down syndrome is one of the most common genetic conditions occurring in one in 700 live births. The trisomy of chromosome 21 causes over-expression of APP which in turn is indicated in the increased production of Aβ associated with AD. This makes DS the most common presenile form of AD exceeding PS1 and PS2 FAD. Since a majority of DS individuals develop dementia, it is important to examine whether DS and sporadic AD share common features, for example, to anticipate shared treatments in the future. Here we explore commonalities and differences for secretases and endosomal pathways in DS and AD. 2013-03-20 /pmc/articles/PMC4000700/ /pubmed/24782952 http://dx.doi.org/10.4172/2161-0460.S7-002 Text en Copyright: © 2013 DeCourt B, et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
DeCourt, Boris
Mobley, William
Reiman, Eric
Shah, Raj Jatin
Sabbagh, Marwan N
Recent Perspectives on APP, Secretases, Endosomal Pathways and How they Influence Alzheimer’s Related Pathological Changes in Down Syndrome
title Recent Perspectives on APP, Secretases, Endosomal Pathways and How they Influence Alzheimer’s Related Pathological Changes in Down Syndrome
title_full Recent Perspectives on APP, Secretases, Endosomal Pathways and How they Influence Alzheimer’s Related Pathological Changes in Down Syndrome
title_fullStr Recent Perspectives on APP, Secretases, Endosomal Pathways and How they Influence Alzheimer’s Related Pathological Changes in Down Syndrome
title_full_unstemmed Recent Perspectives on APP, Secretases, Endosomal Pathways and How they Influence Alzheimer’s Related Pathological Changes in Down Syndrome
title_short Recent Perspectives on APP, Secretases, Endosomal Pathways and How they Influence Alzheimer’s Related Pathological Changes in Down Syndrome
title_sort recent perspectives on app, secretases, endosomal pathways and how they influence alzheimer’s related pathological changes in down syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000700/
https://www.ncbi.nlm.nih.gov/pubmed/24782952
http://dx.doi.org/10.4172/2161-0460.S7-002
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