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Massive Rhabdomyolysis Following Cardiopulmonary Bypass

Here, we report a case of massive rhabdomyolysis following an uncomplicated repair of a ventricular septal defect in a five-month-old baby. Postoperatively, the patient was hemodynamically stable but metabolic acidosis continued, accompanied by fever and delayed mental recovery. The next day, he bec...

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Detalles Bibliográficos
Autores principales: Kim, Young Sam, Yoon, Yong Han, Kim, Joung Taek, Baek, Wan Ki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Thoracic and Cardiovascular Surgery 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000883/
https://www.ncbi.nlm.nih.gov/pubmed/24782976
http://dx.doi.org/10.5090/kjtcs.2014.47.2.181
Descripción
Sumario:Here, we report a case of massive rhabdomyolysis following an uncomplicated repair of a ventricular septal defect in a five-month-old baby. Postoperatively, the patient was hemodynamically stable but metabolic acidosis continued, accompanied by fever and delayed mental recovery. The next day, he became comatose and never regained consciousness thereafter. The computed tomography of the brain revealed a diffuse brain injury. The patient followed a downhill course and eventually died on postoperative day 33. An unusually high level of creatine phosphokinase was noticed, peaking (21,880 IU/L) on postoperative day 2, suggesting severe rhabdomyolysis. The relevant literature was reviewed, and the possibility of malignant hyperthermia obscured by cardiopulmonary bypass and hypothermia was addressed.