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The Combination of Carmustine Wafers and Fotemustine in Recurrent Glioblastoma Patients: A Monoinstitutional Experience

Background. To date, there is no standard treatment for recurrent glioblastoma. We analyzed the feasibility of second surgery plus carmustine wafers followed by intravenous fotemustine. Methods. Retrospectively, we analyzed patients with recurrent glioblastoma treated with this multimodal strategy....

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Autores principales: Lombardi, Giuseppe, Della Puppa, Alessandro, Zustovich, Fable, Pambuku, Ardi, Farina, Patrizia, Fiduccia, Pasquale, Roma, Anna, Zagonel, Vittorina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000952/
https://www.ncbi.nlm.nih.gov/pubmed/24812626
http://dx.doi.org/10.1155/2014/678191
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author Lombardi, Giuseppe
Della Puppa, Alessandro
Zustovich, Fable
Pambuku, Ardi
Farina, Patrizia
Fiduccia, Pasquale
Roma, Anna
Zagonel, Vittorina
author_facet Lombardi, Giuseppe
Della Puppa, Alessandro
Zustovich, Fable
Pambuku, Ardi
Farina, Patrizia
Fiduccia, Pasquale
Roma, Anna
Zagonel, Vittorina
author_sort Lombardi, Giuseppe
collection PubMed
description Background. To date, there is no standard treatment for recurrent glioblastoma. We analyzed the feasibility of second surgery plus carmustine wafers followed by intravenous fotemustine. Methods. Retrospectively, we analyzed patients with recurrent glioblastoma treated with this multimodal strategy. Results. Twenty-four patients were analyzed. The median age was 53.6; all patients had KPS between 90 and 100; 19 patients (79%) performed a gross total resection > 98% and 5 (21%) a gross total resection > 90%. The median progression-free survival from second surgery was 6 months (95% CI 3.9–8.05) and the median OS was 14 months (95% CI 11.1–16.8 months). Toxicity was predominantly haematological: 5 patients (21%) experienced grade 3-4 thrombocytopenia and 3 patients (12%) grade 3-4 leukopenia. Conclusion. This multimodal strategy may be feasible in patients with recurrent glioblastoma, in particular, for patients in good clinical conditions.
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spelling pubmed-40009522014-05-08 The Combination of Carmustine Wafers and Fotemustine in Recurrent Glioblastoma Patients: A Monoinstitutional Experience Lombardi, Giuseppe Della Puppa, Alessandro Zustovich, Fable Pambuku, Ardi Farina, Patrizia Fiduccia, Pasquale Roma, Anna Zagonel, Vittorina Biomed Res Int Clinical Study Background. To date, there is no standard treatment for recurrent glioblastoma. We analyzed the feasibility of second surgery plus carmustine wafers followed by intravenous fotemustine. Methods. Retrospectively, we analyzed patients with recurrent glioblastoma treated with this multimodal strategy. Results. Twenty-four patients were analyzed. The median age was 53.6; all patients had KPS between 90 and 100; 19 patients (79%) performed a gross total resection > 98% and 5 (21%) a gross total resection > 90%. The median progression-free survival from second surgery was 6 months (95% CI 3.9–8.05) and the median OS was 14 months (95% CI 11.1–16.8 months). Toxicity was predominantly haematological: 5 patients (21%) experienced grade 3-4 thrombocytopenia and 3 patients (12%) grade 3-4 leukopenia. Conclusion. This multimodal strategy may be feasible in patients with recurrent glioblastoma, in particular, for patients in good clinical conditions. Hindawi Publishing Corporation 2014 2014-04-09 /pmc/articles/PMC4000952/ /pubmed/24812626 http://dx.doi.org/10.1155/2014/678191 Text en Copyright © 2014 Giuseppe Lombardi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Lombardi, Giuseppe
Della Puppa, Alessandro
Zustovich, Fable
Pambuku, Ardi
Farina, Patrizia
Fiduccia, Pasquale
Roma, Anna
Zagonel, Vittorina
The Combination of Carmustine Wafers and Fotemustine in Recurrent Glioblastoma Patients: A Monoinstitutional Experience
title The Combination of Carmustine Wafers and Fotemustine in Recurrent Glioblastoma Patients: A Monoinstitutional Experience
title_full The Combination of Carmustine Wafers and Fotemustine in Recurrent Glioblastoma Patients: A Monoinstitutional Experience
title_fullStr The Combination of Carmustine Wafers and Fotemustine in Recurrent Glioblastoma Patients: A Monoinstitutional Experience
title_full_unstemmed The Combination of Carmustine Wafers and Fotemustine in Recurrent Glioblastoma Patients: A Monoinstitutional Experience
title_short The Combination of Carmustine Wafers and Fotemustine in Recurrent Glioblastoma Patients: A Monoinstitutional Experience
title_sort combination of carmustine wafers and fotemustine in recurrent glioblastoma patients: a monoinstitutional experience
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000952/
https://www.ncbi.nlm.nih.gov/pubmed/24812626
http://dx.doi.org/10.1155/2014/678191
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