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Potential Therapeutic Effects of Neurotrophins for Acute and Chronic Neurological Diseases

The neurotrophins (NTs) nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), NT-3, and NT-4/5 are proteins that regulate cell proliferation, differentiation, and survival in both the developing and mature central nervous system (CNS) by binding to two receptor classes, Trk receptors...

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Detalles Bibliográficos
Autores principales: Cai, Junying, Hua, Fuzhou, Yuan, Linhui, Tang, Wei, Lu, Jun, Yu, Shuchun, Wang, Xifeng, Hu, Yanhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000962/
https://www.ncbi.nlm.nih.gov/pubmed/24818146
http://dx.doi.org/10.1155/2014/601084
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author Cai, Junying
Hua, Fuzhou
Yuan, Linhui
Tang, Wei
Lu, Jun
Yu, Shuchun
Wang, Xifeng
Hu, Yanhui
author_facet Cai, Junying
Hua, Fuzhou
Yuan, Linhui
Tang, Wei
Lu, Jun
Yu, Shuchun
Wang, Xifeng
Hu, Yanhui
author_sort Cai, Junying
collection PubMed
description The neurotrophins (NTs) nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), NT-3, and NT-4/5 are proteins that regulate cell proliferation, differentiation, and survival in both the developing and mature central nervous system (CNS) by binding to two receptor classes, Trk receptors and p75 NTR. Motivated by the broad growth- and survival-promoting effects of these proteins, numerous studies have attempted to use exogenous NTs to prevent the death of cells that are associated with neurological disease or promote the regeneration of severed axons caused by mechanical injury. Indeed, such neurotrophic effects have been repeatedly demonstrated in animal models of stroke, nerve injury, and neurodegenerative disease. However, limitations, including the short biological half-lives and poor blood-brain permeability of these proteins, prevent routine application from treating human disease. In this report, we reviewed evidence for the neuroprotective efficacy of NTs in animal models, highlighting outstanding technical challenges and discussing more recent attempts to harness the neuroprotective capacity of endogenous NTs using small molecule inducers and cell transplantation.
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spelling pubmed-40009622014-05-11 Potential Therapeutic Effects of Neurotrophins for Acute and Chronic Neurological Diseases Cai, Junying Hua, Fuzhou Yuan, Linhui Tang, Wei Lu, Jun Yu, Shuchun Wang, Xifeng Hu, Yanhui Biomed Res Int Review Article The neurotrophins (NTs) nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), NT-3, and NT-4/5 are proteins that regulate cell proliferation, differentiation, and survival in both the developing and mature central nervous system (CNS) by binding to two receptor classes, Trk receptors and p75 NTR. Motivated by the broad growth- and survival-promoting effects of these proteins, numerous studies have attempted to use exogenous NTs to prevent the death of cells that are associated with neurological disease or promote the regeneration of severed axons caused by mechanical injury. Indeed, such neurotrophic effects have been repeatedly demonstrated in animal models of stroke, nerve injury, and neurodegenerative disease. However, limitations, including the short biological half-lives and poor blood-brain permeability of these proteins, prevent routine application from treating human disease. In this report, we reviewed evidence for the neuroprotective efficacy of NTs in animal models, highlighting outstanding technical challenges and discussing more recent attempts to harness the neuroprotective capacity of endogenous NTs using small molecule inducers and cell transplantation. Hindawi Publishing Corporation 2014 2014-04-09 /pmc/articles/PMC4000962/ /pubmed/24818146 http://dx.doi.org/10.1155/2014/601084 Text en Copyright © 2014 Junying Cai et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Cai, Junying
Hua, Fuzhou
Yuan, Linhui
Tang, Wei
Lu, Jun
Yu, Shuchun
Wang, Xifeng
Hu, Yanhui
Potential Therapeutic Effects of Neurotrophins for Acute and Chronic Neurological Diseases
title Potential Therapeutic Effects of Neurotrophins for Acute and Chronic Neurological Diseases
title_full Potential Therapeutic Effects of Neurotrophins for Acute and Chronic Neurological Diseases
title_fullStr Potential Therapeutic Effects of Neurotrophins for Acute and Chronic Neurological Diseases
title_full_unstemmed Potential Therapeutic Effects of Neurotrophins for Acute and Chronic Neurological Diseases
title_short Potential Therapeutic Effects of Neurotrophins for Acute and Chronic Neurological Diseases
title_sort potential therapeutic effects of neurotrophins for acute and chronic neurological diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000962/
https://www.ncbi.nlm.nih.gov/pubmed/24818146
http://dx.doi.org/10.1155/2014/601084
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