Some Basic Aspects of HLA-G Biology

Human leukocyte antigen-G (HLA-G) is a low polymorphic nonclassical HLA-I molecule restrictively expressed and with suppressive functions. HLA-G gene products are quite complex, with seven HLA-G isoforms, four membrane bound, and other three soluble isoforms that can suffer different posttranslation...

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Detalles Bibliográficos
Autores principales: Alegre, Estibaliz, Rizzo, Roberta, Bortolotti, Daria, Fernandez-Landázuri, Sara, Fainardi, Enrico, González, Alvaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000973/
https://www.ncbi.nlm.nih.gov/pubmed/24818168
http://dx.doi.org/10.1155/2014/657625
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author Alegre, Estibaliz
Rizzo, Roberta
Bortolotti, Daria
Fernandez-Landázuri, Sara
Fainardi, Enrico
González, Alvaro
author_facet Alegre, Estibaliz
Rizzo, Roberta
Bortolotti, Daria
Fernandez-Landázuri, Sara
Fainardi, Enrico
González, Alvaro
author_sort Alegre, Estibaliz
collection PubMed
description Human leukocyte antigen-G (HLA-G) is a low polymorphic nonclassical HLA-I molecule restrictively expressed and with suppressive functions. HLA-G gene products are quite complex, with seven HLA-G isoforms, four membrane bound, and other three soluble isoforms that can suffer different posttranslational modifications or even complex formations. In addition, HLA-G has been described included in exosomes. In this review we will focus on HLA-G biochemistry with special emphasis to the mechanisms that regulate its expression and how the protein modifications affect the quantification in biological fluids.
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spelling pubmed-40009732014-05-11 Some Basic Aspects of HLA-G Biology Alegre, Estibaliz Rizzo, Roberta Bortolotti, Daria Fernandez-Landázuri, Sara Fainardi, Enrico González, Alvaro J Immunol Res Review Article Human leukocyte antigen-G (HLA-G) is a low polymorphic nonclassical HLA-I molecule restrictively expressed and with suppressive functions. HLA-G gene products are quite complex, with seven HLA-G isoforms, four membrane bound, and other three soluble isoforms that can suffer different posttranslational modifications or even complex formations. In addition, HLA-G has been described included in exosomes. In this review we will focus on HLA-G biochemistry with special emphasis to the mechanisms that regulate its expression and how the protein modifications affect the quantification in biological fluids. Hindawi Publishing Corporation 2014 2014-04-09 /pmc/articles/PMC4000973/ /pubmed/24818168 http://dx.doi.org/10.1155/2014/657625 Text en Copyright © 2014 Estibaliz Alegre et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Alegre, Estibaliz
Rizzo, Roberta
Bortolotti, Daria
Fernandez-Landázuri, Sara
Fainardi, Enrico
González, Alvaro
Some Basic Aspects of HLA-G Biology
title Some Basic Aspects of HLA-G Biology
title_full Some Basic Aspects of HLA-G Biology
title_fullStr Some Basic Aspects of HLA-G Biology
title_full_unstemmed Some Basic Aspects of HLA-G Biology
title_short Some Basic Aspects of HLA-G Biology
title_sort some basic aspects of hla-g biology
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000973/
https://www.ncbi.nlm.nih.gov/pubmed/24818168
http://dx.doi.org/10.1155/2014/657625
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