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DNA damage repair machinery and HIV escape from innate immune sensing
Viruses have been long known to perturb cell cycle regulators and key players of the DNA damage response to benefit their life cycles. In the case of the human immunodeficiency virus (HIV), the viral auxiliary protein Vpr activates the structure-specific endonuclease SLX4 complex to promote escape f...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001025/ https://www.ncbi.nlm.nih.gov/pubmed/24795708 http://dx.doi.org/10.3389/fmicb.2014.00176 |
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author | Brégnard, Christelle Benkirane, Monsef Laguette, Nadine |
author_facet | Brégnard, Christelle Benkirane, Monsef Laguette, Nadine |
author_sort | Brégnard, Christelle |
collection | PubMed |
description | Viruses have been long known to perturb cell cycle regulators and key players of the DNA damage response to benefit their life cycles. In the case of the human immunodeficiency virus (HIV), the viral auxiliary protein Vpr activates the structure-specific endonuclease SLX4 complex to promote escape from innate immune sensing and, as a side effect, induces replication stress in cycling cells and subsequent cell cycle arrest at the G2/M transition. This novel pathway subverted by HIV to prevent accumulation of viral reverse transcription by-products adds up to facilitating effects of major cellular exonucleases that degrade pathological DNA species. Within this review we discuss the impact of this finding on our understanding of the interplay between HIV replication and nucleic acid metabolism and its implications for cancer-related chronic inflammation. |
format | Online Article Text |
id | pubmed-4001025 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-40010252014-05-02 DNA damage repair machinery and HIV escape from innate immune sensing Brégnard, Christelle Benkirane, Monsef Laguette, Nadine Front Microbiol Microbiology Viruses have been long known to perturb cell cycle regulators and key players of the DNA damage response to benefit their life cycles. In the case of the human immunodeficiency virus (HIV), the viral auxiliary protein Vpr activates the structure-specific endonuclease SLX4 complex to promote escape from innate immune sensing and, as a side effect, induces replication stress in cycling cells and subsequent cell cycle arrest at the G2/M transition. This novel pathway subverted by HIV to prevent accumulation of viral reverse transcription by-products adds up to facilitating effects of major cellular exonucleases that degrade pathological DNA species. Within this review we discuss the impact of this finding on our understanding of the interplay between HIV replication and nucleic acid metabolism and its implications for cancer-related chronic inflammation. Frontiers Media S.A. 2014-04-22 /pmc/articles/PMC4001025/ /pubmed/24795708 http://dx.doi.org/10.3389/fmicb.2014.00176 Text en Copyright © 2014 Brégnard, Benkirane and Laguette. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Brégnard, Christelle Benkirane, Monsef Laguette, Nadine DNA damage repair machinery and HIV escape from innate immune sensing |
title | DNA damage repair machinery and HIV escape from innate immune sensing |
title_full | DNA damage repair machinery and HIV escape from innate immune sensing |
title_fullStr | DNA damage repair machinery and HIV escape from innate immune sensing |
title_full_unstemmed | DNA damage repair machinery and HIV escape from innate immune sensing |
title_short | DNA damage repair machinery and HIV escape from innate immune sensing |
title_sort | dna damage repair machinery and hiv escape from innate immune sensing |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001025/ https://www.ncbi.nlm.nih.gov/pubmed/24795708 http://dx.doi.org/10.3389/fmicb.2014.00176 |
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