Chemotherapeutic Compounds Targeting the DNA Double-Strand Break Repair Pathways: The Good, the Bad, and the Promising

The repair of DNA double-strand breaks (DSBs) is a critical cellular mechanism that exists to ensure genomic stability. DNA DSBs are the most deleterious type of insult to a cell’s genetic material and can lead to genomic instability, apoptosis, or senescence. Incorrectly repaired DNA DSBs have the...

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Detalles Bibliográficos
Autores principales: Jekimovs, Christian, Bolderson, Emma, Suraweera, Amila, Adams, Mark, O’Byrne, Kenneth J., Richard, Derek J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001069/
https://www.ncbi.nlm.nih.gov/pubmed/24795863
http://dx.doi.org/10.3389/fonc.2014.00086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001069/
https://www.ncbi.nlm.nih.gov/pubmed/24795863
http://dx.doi.org/10.3389/fonc.2014.00086

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