Cargando…

Chemotherapeutic Compounds Targeting the DNA Double-Strand Break Repair Pathways: The Good, the Bad, and the Promising

The repair of DNA double-strand breaks (DSBs) is a critical cellular mechanism that exists to ensure genomic stability. DNA DSBs are the most deleterious type of insult to a cell’s genetic material and can lead to genomic instability, apoptosis, or senescence. Incorrectly repaired DNA DSBs have the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jekimovs, Christian, Bolderson, Emma, Suraweera, Amila, Adams, Mark, O’Byrne, Kenneth J., Richard, Derek J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2014
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001069/ https://www.ncbi.nlm.nih.gov/pubmed/24795863 http://dx.doi.org/10.3389/fonc.2014.00086

Ejemplares similares

COMMD1, from the Repair of DNA Double Strand Breaks, to a Novel Anti-Cancer Therapeutic Target
por: Suraweera, Amila, et al.
Publicado: (2021)

The fructose-bisphosphate, Aldolase A (ALDOA), facilitates DNA-PKcs and ATM kinase activity to regulate DNA double-strand break repair
por: Sobanski, Thais, et al.
Publicado: (2023)

Epigenetic Mechanisms in DNA Double Strand Break Repair: A Clinical Review
por: Fernandez, Alejandra, et al.
Publicado: (2021)

Cell Metabolism and DNA Repair Pathways: Implications for Cancer Therapy
por: Sobanski, Thais, et al.
Publicado: (2021)

COMMD4 functions with the histone H2A-H2B dimer for the timely repair of DNA double-strand breaks
por: Suraweera, Amila, et al.
Publicado: (2021)

Barrier-to-autointegration-factor (Banf1) modulates DNA double-strand break repair pathway choice via regulation of DNA-dependent kinase (DNA-PK) activity
por: Burgess, Joshua T, et al.
Publicado: (2021)

Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks
por: Bolderson, Emma, et al.
Publicado: (2014)

Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks
por: Bolderson, Emma, et al.
Publicado: (2010)

Human single-stranded DNA binding proteins are essential for maintaining genomic stability
por: Ashton, Nicholas W, et al.
Publicado: (2013)

Defining COMMD4 as an anti-cancer therapeutic target and prognostic factor in non-small cell lung cancer
por: Suraweera, Amila, et al.
Publicado: (2020)

Correction: Defining COMMD4 as an anti-cancer therapeutic target and prognostic factor in non-small cell lung cancer
por: Suraweera, Amila, et al.
Publicado: (2021)

Combination Therapy With Histone Deacetylase Inhibitors (HDACi) for the Treatment of Cancer: Achieving the Full Therapeutic Potential of HDACi
por: Suraweera, Amila, et al.
Publicado: (2018)

Models of osteoarthritis: the good, the bad and the promising
por: Cope, P.J., et al.
Publicado: (2019)

Néstor-Guillermo Progeria Syndrome: a biochemical insight into Barrier-to-Autointegration Factor 1, alanine 12 threonine mutation
por: Paquet, Nicolas, et al.
Publicado: (2014)

Chronic infections with viruses or parasites: breaking bad to make good
por: Godkin, Andrew, et al.
Publicado: (2017)

Beyond PARP1: The Potential of Other Members of the Poly (ADP-Ribose) Polymerase Family in DNA Repair and Cancer Therapeutics
por: Richard, Iain A., et al.
Publicado: (2022)

Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy
por: Kildey, Katrina, et al.
Publicado: (2021)

RBM6 splicing factor promotes homologous recombination repair of double-strand breaks and modulates sensitivity to chemotherapeutic drugs
por: Machour, Feras E, et al.
Publicado: (2021)

Breaking bad
por: Bhattacharya, Mohini, et al.
Publicado: (2023)

Tumor Hypoxia Drives Genomic Instability
por: Tang, Ming, et al.
Publicado: (2021)

Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage
por: Bolderson, Emma, et al.
Publicado: (2019)

PARP Inhibitors: Clinical Relevance, Mechanisms of Action and Tumor Resistance
por: Rose, Maddison, et al.
Publicado: (2020)

The role of inner nuclear membrane proteins in tumourigenesis and as potential targets for cancer therapy
por: Rose, Maddison, et al.
Publicado: (2022)

Pathological mutations in PNKP trigger defects in DNA single-strand break repair but not DNA double-strand break repair
por: Kalasova, Ilona, et al.
Publicado: (2020)

‘BREAKS’ Protocol for Breaking Bad News
por: Narayanan, Vijayakumar, et al.
Publicado: (2010)

Breaking Bad News
por: Foster, Ryan
Publicado: (2005)

hSSB1 (NABP2/ OBFC2B) is required for the repair of 8-oxo-guanine by the hOGG1-mediated base excision repair pathway
por: Paquet, Nicolas, et al.
Publicado: (2015)

Repair of DNA Double-Strand Breaks in Heterochromatin
por: Watts, Felicity Z.
Publicado: (2016)

hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity
por: Richard, Derek J., et al.
Publicado: (2011)

From good to bad fibroblasts: New promising targets to cure Chron's disease
por: Gianluca, Cipriani
Publicado: (2021)

Double-strand break repair-adox: Restoration of suppressed double-strand break repair during mitosis induces genomic instability
por: Terasawa, Masahiro, et al.
Publicado: (2014)

Good and bad fever
por: Cavaillon, Jean-Marc
Publicado: (2012)

Aggression—Good or Bad?
por: Ratcliffe, T. A.
Publicado: (1962)

Good and Bad Teeth
Publicado: (1869)

The Good, the Bad and the Tick
por: Cabezas-Cruz, Alejandro, et al.
Publicado: (2019)

Good and Bad Filters
por: Bissell, Wm. G.
Publicado: (1912)

Eggs Good and Bad
Publicado: (1870)

Good and Bad Medicines
Publicado: (1873)

The Therapeutic Potential of DNA Damage Repair Pathways and Genomic Stability in Lung Cancer
por: Burgess, Joshua T., et al.
Publicado: (2020)

Nucleophosmin: from structure and function to disease development
por: Box, Joseph K., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_lhld527qp6d8co1t9epi6non50