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Vitamin D, folate, and potential early lifecycle environmental origin of significant adult phenotypes
Background and objectives: Vitamin D and folate are highly UV sensitive, and critical for maintaining health throughout the lifecycle. This study examines whether solar irradiance during the first trimester of pregnancy influences vitamin D receptor (VDR) and nuclear folate gene variant occurrence,...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001294/ https://www.ncbi.nlm.nih.gov/pubmed/24699387 http://dx.doi.org/10.1093/emph/eou013 |
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author | Lucock, Mark Yates, Zoë Martin, Charlotte Choi, Jeong-Hwa Boyd, Lyndell Tang, Sa Naumovski, Nenad Furst, John Roach, Paul Jablonski, Nina Chaplin, George Veysey, Martin |
author_facet | Lucock, Mark Yates, Zoë Martin, Charlotte Choi, Jeong-Hwa Boyd, Lyndell Tang, Sa Naumovski, Nenad Furst, John Roach, Paul Jablonski, Nina Chaplin, George Veysey, Martin |
author_sort | Lucock, Mark |
collection | PubMed |
description | Background and objectives: Vitamin D and folate are highly UV sensitive, and critical for maintaining health throughout the lifecycle. This study examines whether solar irradiance during the first trimester of pregnancy influences vitamin D receptor (VDR) and nuclear folate gene variant occurrence, and whether affected genes influence late-life biochemical/clinical phenotypes. Methodology: 228 subjects were examined for periconceptional exposure to solar irradiance, variation in vitamin D/folate genes (polymerase chain reaction (PCR)), dietary intake (food frequency questionnaire (FFQ)) and important adult biochemical/clinical phenotypes. Results: Periconceptional solar irradiance was associated with VDR-BsmI (P = 0.0008(wk7)), TaqI (P = 0.0014(wk7)) and EcoRV (P = 0.0030(wk6)) variant occurrence between post-conceptional weeks 6–8, a period when ossification begins. Similar effects were detected for other VDR gene polymorphisms. Periconceptional solar irradiance was also associated with 19 bp del-DHFR (P = 0.0025(wk6)), and to a lesser extent C1420T-SHMT (P = 0.0249(wk6)), a folate-critical time during embryogenesis. These same genes were associated with several late-life phenotypes: VDR-BsmI, TaqI and ApaI determined the relationship between dietary vitamin D and both insulin (P < 0.0001/BB, 0.0007/tt and 0.0173/AA, respectively) and systolic blood pressure (P = 0.0290/Bb, 0.0299/Tt and 0.0412/AA, respectively), making them important early and late in the lifecycle. While these and other phenotype associations were found for the VDR variants, folate polymorphism associations in later-life were limited to C1420T-SHMT (P = 0.0037 and 0.0297 for fasting blood glucose and HbA1c levels, respectively). We additionally report nutrient–gene relationships with body mass index, thiol/folate metabolome, cognition, depression and hypertension. Furthermore, photoperiod at conception influenced occurrence of VDR-Tru9I and 2R3R-TS genotypes (P = 0.0120 and 0.0360, respectively). Conclusions and implications: Findings identify environmental and nutritional agents that may interact to modify gene–phenotype relationships across the lifecycle, offering new insight into human ecology. This includes factors related to both disease aetiology and the evolution of skin pigmentation. |
format | Online Article Text |
id | pubmed-4001294 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-40012942014-04-28 Vitamin D, folate, and potential early lifecycle environmental origin of significant adult phenotypes Lucock, Mark Yates, Zoë Martin, Charlotte Choi, Jeong-Hwa Boyd, Lyndell Tang, Sa Naumovski, Nenad Furst, John Roach, Paul Jablonski, Nina Chaplin, George Veysey, Martin Evol Med Public Health Original Research Article Background and objectives: Vitamin D and folate are highly UV sensitive, and critical for maintaining health throughout the lifecycle. This study examines whether solar irradiance during the first trimester of pregnancy influences vitamin D receptor (VDR) and nuclear folate gene variant occurrence, and whether affected genes influence late-life biochemical/clinical phenotypes. Methodology: 228 subjects were examined for periconceptional exposure to solar irradiance, variation in vitamin D/folate genes (polymerase chain reaction (PCR)), dietary intake (food frequency questionnaire (FFQ)) and important adult biochemical/clinical phenotypes. Results: Periconceptional solar irradiance was associated with VDR-BsmI (P = 0.0008(wk7)), TaqI (P = 0.0014(wk7)) and EcoRV (P = 0.0030(wk6)) variant occurrence between post-conceptional weeks 6–8, a period when ossification begins. Similar effects were detected for other VDR gene polymorphisms. Periconceptional solar irradiance was also associated with 19 bp del-DHFR (P = 0.0025(wk6)), and to a lesser extent C1420T-SHMT (P = 0.0249(wk6)), a folate-critical time during embryogenesis. These same genes were associated with several late-life phenotypes: VDR-BsmI, TaqI and ApaI determined the relationship between dietary vitamin D and both insulin (P < 0.0001/BB, 0.0007/tt and 0.0173/AA, respectively) and systolic blood pressure (P = 0.0290/Bb, 0.0299/Tt and 0.0412/AA, respectively), making them important early and late in the lifecycle. While these and other phenotype associations were found for the VDR variants, folate polymorphism associations in later-life were limited to C1420T-SHMT (P = 0.0037 and 0.0297 for fasting blood glucose and HbA1c levels, respectively). We additionally report nutrient–gene relationships with body mass index, thiol/folate metabolome, cognition, depression and hypertension. Furthermore, photoperiod at conception influenced occurrence of VDR-Tru9I and 2R3R-TS genotypes (P = 0.0120 and 0.0360, respectively). Conclusions and implications: Findings identify environmental and nutritional agents that may interact to modify gene–phenotype relationships across the lifecycle, offering new insight into human ecology. This includes factors related to both disease aetiology and the evolution of skin pigmentation. Oxford University Press 2014-04-02 /pmc/articles/PMC4001294/ /pubmed/24699387 http://dx.doi.org/10.1093/emph/eou013 Text en © The Author(s) 2014. Published by Oxford University Press on behalf of the Foundation for Evolution, Medicine, and Public Health. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Article Lucock, Mark Yates, Zoë Martin, Charlotte Choi, Jeong-Hwa Boyd, Lyndell Tang, Sa Naumovski, Nenad Furst, John Roach, Paul Jablonski, Nina Chaplin, George Veysey, Martin Vitamin D, folate, and potential early lifecycle environmental origin of significant adult phenotypes |
title | Vitamin D, folate, and potential early lifecycle environmental origin of significant adult phenotypes |
title_full | Vitamin D, folate, and potential early lifecycle environmental origin of significant adult phenotypes |
title_fullStr | Vitamin D, folate, and potential early lifecycle environmental origin of significant adult phenotypes |
title_full_unstemmed | Vitamin D, folate, and potential early lifecycle environmental origin of significant adult phenotypes |
title_short | Vitamin D, folate, and potential early lifecycle environmental origin of significant adult phenotypes |
title_sort | vitamin d, folate, and potential early lifecycle environmental origin of significant adult phenotypes |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001294/ https://www.ncbi.nlm.nih.gov/pubmed/24699387 http://dx.doi.org/10.1093/emph/eou013 |
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