Reduced IRE1α mediates apoptotic cell death by disrupting calcium homeostasis via the InsP3 receptor

The endoplasmic reticulum (ER) is not only a home for folding and posttranslational modifications of secretory proteins but also a reservoir for intracellular Ca(2+). Perturbation of ER homeostasis contributes to the pathogenesis of various neurodegenerative diseases, such as Alzheimer's and Pa...

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Detalles Bibliográficos
Autores principales: Son, S M, Byun, J, Roh, S-E, Kim, S J, Mook-Jung, I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001297/
https://www.ncbi.nlm.nih.gov/pubmed/24743743
http://dx.doi.org/10.1038/cddis.2014.129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001297/
https://www.ncbi.nlm.nih.gov/pubmed/24743743
http://dx.doi.org/10.1038/cddis.2014.129

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