Epigenetic modification of Nrf2 in 5-fluorouracil-resistant colon cancer cells: involvement of TET-dependent DNA demethylation

5-Fluorouracil (5-FU) is a widely used anticancer drug for the treatment of colorectal cancer (CRC). However, resistance to 5-FU often prevents the success of chemotherapy. Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a transcriptional regulator and a possible target to overcome 5-FU resist...

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Detalles Bibliográficos
Autores principales: Kang, K A, Piao, M J, Kim, K C, Kang, H K, Chang, W Y, Park, I C, Keum, Y S, Surh, Y J, Hyun, J W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001304/
https://www.ncbi.nlm.nih.gov/pubmed/24743738
http://dx.doi.org/10.1038/cddis.2014.149

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