The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response

The epigenetic sensor BRD4 (bromodomain protein 4) is a potent target for anti-cancer therapies. To study the transcriptional impact of BRD4 in cancer, we generated an expression signature of BRD4 knockdown cells and found oxidative stress response genes significantly enriched. We integrated the RNA...

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Detalles Bibliográficos
Autores principales: Hussong, M, Börno, S T, Kerick, M, Wunderlich, A, Franz, A, Sültmann, H, Timmermann, B, Lehrach, H, Hirsch-Kauffmann, M, Schweiger, M R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001311/
https://www.ncbi.nlm.nih.gov/pubmed/24763052
http://dx.doi.org/10.1038/cddis.2014.157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001311/
https://www.ncbi.nlm.nih.gov/pubmed/24763052
http://dx.doi.org/10.1038/cddis.2014.157

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