A gain-of-function mutant p53–HSF1 feed forward circuit governs adaptation of cancer cells to proteotoxic stress

To overcome proteotoxic stress inherent to malignant transformation, cancer cells induce a range of adaptive mechanisms, with the master transcription factor heat-shock factor 1 (HSF1)-orchestrated response taking center stage. Here we define a novel gain-of-function of mutant p53 (mutp53), whereby...

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Detalles Bibliográficos
Autores principales: Li, D, Yallowitz, A, Ozog, L, Marchenko, N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001312/
https://www.ncbi.nlm.nih.gov/pubmed/24763051
http://dx.doi.org/10.1038/cddis.2014.158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001312/
https://www.ncbi.nlm.nih.gov/pubmed/24763051
http://dx.doi.org/10.1038/cddis.2014.158

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