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Thienoquinolines as Novel Disruptors of the PKCε/RACK2 Protein–Protein Interaction

[Image: see text] Ten protein kinase C (PKC) isozymes play divergent roles in signal transduction. Because of sequence similarities, it is particularly difficult to generate isozyme-selective small molecule inhibitors. In order to identify such a selective binder, we derived a pharmacophore model fr...

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Detalles Bibliográficos
Autores principales:	Rechfeld, Florian, Gruber, Peter, Kirchmair, Johannes, Boehler, Markus, Hauser, Nina, Hechenberger, Georg, Garczarczyk, Dorota, Lapa, Gennady B., Preobrazhenskaya, Maria N., Goekjian, Peter, Langer, Thierry, Hofmann, Johann
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001449/ https://www.ncbi.nlm.nih.gov/pubmed/24712764 http://dx.doi.org/10.1021/jm401605c

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