Enantioselective Silyl Protection of Alcohols Promoted by a Combination of Chiral and Achiral Lewis Basic Catalysts

Catalytic enantioselective mono-silylations of diols and polyols furnish valuable alcohol-containing molecules in high enantiomeric purity. These transformations, however, require high catalyst loadings (20-30 mol%) and long reaction times (2-5 days). Here, we report that a counterintuitive strategy...

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Detalles Bibliográficos
Autores principales: Manville, Nathan, Alite, Hekla, Haeffner, Fredrik, Hoveyda, Amir H., Snapper, Marc L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001701/
https://www.ncbi.nlm.nih.gov/pubmed/23965679
http://dx.doi.org/10.1038/nchem.1708

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001701/
https://www.ncbi.nlm.nih.gov/pubmed/23965679
http://dx.doi.org/10.1038/nchem.1708

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