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Purine Pathway Implicated in Mechanism of Resistance to Aspirin Therapy: Pharmacometabolomics-Informed-Pharmacogenomics

Though aspirin is a well-established antiplatelet agent, the mechanisms of aspirin resistance remain poorly understood. Metabolomics allows for measurement of hundreds of small molecules in biological samples enabling detailed mapping of pathways involved in drug response. We defined the metabolic s...

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Detalles Bibliográficos
Autores principales:	Yerges-Armstrong, Laura M., Ellero-Simatos, Sandrine, Georgiades, Anastasia, Zhu, Hongjie, Lewis, Joshua, Horenstein, Richard B., Beitelshees, Amber L., Dane, Adrie, Reijmers, Theo, Hankemeier, Thomas, Fiehn, Oliver, Shuldiner, Alan R., Kaddurah-Daouk, Rima
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001726/ https://www.ncbi.nlm.nih.gov/pubmed/23839601 http://dx.doi.org/10.1038/clpt.2013.119

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