Activation of the Ano1 (TMEM16A) chloride channel by calcium is not mediated by calmodulin

The Ca(2+)-activated Cl channel anoctamin-1 (Ano1; Tmem16A) plays a variety of physiological roles, including epithelial fluid secretion. Ano1 is activated by increases in intracellular Ca(2+), but there is uncertainty whether Ca(2+) binds directly to Ano1 or whether phosphorylation or additional Ca...

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Detalles Bibliográficos
Autores principales: Yu, Kuai, Zhu, Jinqiu, Qu, Zhiqiang, Cui, Yuan-Yuan, Hartzell, H. Criss
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001774/
https://www.ncbi.nlm.nih.gov/pubmed/24420770
http://dx.doi.org/10.1085/jgp.201311047

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