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Evolutionary imprint of activation: The design principles of VSDs
Voltage-sensor domains (VSDs) are modular biomolecular machines that transduce electrical signals in cells through a highly conserved activation mechanism. Here, we investigate sequence–function relationships in VSDs with approaches from information theory and probabilistic modeling. Specifically, w...
Autores principales: | Palovcak, Eugene, Delemotte, Lucie, Klein, Michael L., Carnevale, Vincenzo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001776/ https://www.ncbi.nlm.nih.gov/pubmed/24470486 http://dx.doi.org/10.1085/jgp.201311103 |
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