Cargando…

Pilot study of hemoglobinopathies in newborns of the Rafael Calvo maternity clinic of Cartagena, Colombia

INTRODUCTION: The hemoglobinopathies are a heterogeneous group of congenital anemias from Africa, Asia and the Mediterranean. Due to the migration of this population have spread worldwide, especially in Latin America and the Caribbean region, which Cartagena de Indias is included, with a large propo...

Descripción completa

Detalles Bibliográficos
Autores principales: Alvear, Ciro Cesar, Barboza, Miriam, Viola, Maricela, Moneriz, Carlos, Araque, Luz Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Universidad del Valle 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001955/
https://www.ncbi.nlm.nih.gov/pubmed/24893191
_version_ 1782313764511547392
author Alvear, Ciro Cesar
Barboza, Miriam
Viola, Maricela
Moneriz, Carlos
Araque, Luz Marina
author_facet Alvear, Ciro Cesar
Barboza, Miriam
Viola, Maricela
Moneriz, Carlos
Araque, Luz Marina
author_sort Alvear, Ciro Cesar
collection PubMed
description INTRODUCTION: The hemoglobinopathies are a heterogeneous group of congenital anemias from Africa, Asia and the Mediterranean. Due to the migration of this population have spread worldwide, especially in Latin America and the Caribbean region, which Cartagena de Indias is included, with a large proportion of people of African descent. The lack of routine programs that include an appropriate methodology for precise identification of those affected and carriers, impossible to know the real behavior of this disease in our country and an early and appropriate to the patients before the disease manifests itself and produce its serious consequences. OBJECTIVE: To estimate the incidence and describe the epidemiological profile of hemoglobinopathies in newborns Rafael Calvo Maternity Clinic of Cartagena, in the period from January to June 2010. METHODS: Prospective descriptive study of a population of 1,729 newborns. Samples were collected cord blood on filter paper. Isoelectric focusing electrophoresis (IEF )was used to separate the haemoglobins. RESULTS: 94.4% (1,633 samples) were normal (hemoglobin FA), 4.5% (78 samples) were heterozygous for haemoglobin S (HbFAS), 1% (17samples) were heterozygous for haemoglobin C (hemoglobin FAC) and 0.1% (1 sample) was double heterozygous SC (hemoglobin FSC). CONCLUSION: Due to the high incidence of hemoglobinopathies found in this pilot study highlights the importance and necessity of establishing an obligatory neonatal screening in the city of Cartagena, in order to make a timely diagnosis and monitoring of affected and carrier.
format Online
Article
Text
id pubmed-4001955
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Universidad del Valle
record_format MEDLINE/PubMed
spelling pubmed-40019552014-06-02 Pilot study of hemoglobinopathies in newborns of the Rafael Calvo maternity clinic of Cartagena, Colombia Alvear, Ciro Cesar Barboza, Miriam Viola, Maricela Moneriz, Carlos Araque, Luz Marina Colomb Med (Cali) Original Article INTRODUCTION: The hemoglobinopathies are a heterogeneous group of congenital anemias from Africa, Asia and the Mediterranean. Due to the migration of this population have spread worldwide, especially in Latin America and the Caribbean region, which Cartagena de Indias is included, with a large proportion of people of African descent. The lack of routine programs that include an appropriate methodology for precise identification of those affected and carriers, impossible to know the real behavior of this disease in our country and an early and appropriate to the patients before the disease manifests itself and produce its serious consequences. OBJECTIVE: To estimate the incidence and describe the epidemiological profile of hemoglobinopathies in newborns Rafael Calvo Maternity Clinic of Cartagena, in the period from January to June 2010. METHODS: Prospective descriptive study of a population of 1,729 newborns. Samples were collected cord blood on filter paper. Isoelectric focusing electrophoresis (IEF )was used to separate the haemoglobins. RESULTS: 94.4% (1,633 samples) were normal (hemoglobin FA), 4.5% (78 samples) were heterozygous for haemoglobin S (HbFAS), 1% (17samples) were heterozygous for haemoglobin C (hemoglobin FAC) and 0.1% (1 sample) was double heterozygous SC (hemoglobin FSC). CONCLUSION: Due to the high incidence of hemoglobinopathies found in this pilot study highlights the importance and necessity of establishing an obligatory neonatal screening in the city of Cartagena, in order to make a timely diagnosis and monitoring of affected and carrier. Universidad del Valle 2012-09-30 /pmc/articles/PMC4001955/ /pubmed/24893191 Text en Copyright: © 2013 Universidad del Valle. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Alvear, Ciro Cesar
Barboza, Miriam
Viola, Maricela
Moneriz, Carlos
Araque, Luz Marina
Pilot study of hemoglobinopathies in newborns of the Rafael Calvo maternity clinic of Cartagena, Colombia
title Pilot study of hemoglobinopathies in newborns of the Rafael Calvo maternity clinic of Cartagena, Colombia
title_full Pilot study of hemoglobinopathies in newborns of the Rafael Calvo maternity clinic of Cartagena, Colombia
title_fullStr Pilot study of hemoglobinopathies in newborns of the Rafael Calvo maternity clinic of Cartagena, Colombia
title_full_unstemmed Pilot study of hemoglobinopathies in newborns of the Rafael Calvo maternity clinic of Cartagena, Colombia
title_short Pilot study of hemoglobinopathies in newborns of the Rafael Calvo maternity clinic of Cartagena, Colombia
title_sort pilot study of hemoglobinopathies in newborns of the rafael calvo maternity clinic of cartagena, colombia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001955/
https://www.ncbi.nlm.nih.gov/pubmed/24893191
work_keys_str_mv AT alvearcirocesar pilotstudyofhemoglobinopathiesinnewbornsoftherafaelcalvomaternityclinicofcartagenacolombia
AT barbozamiriam pilotstudyofhemoglobinopathiesinnewbornsoftherafaelcalvomaternityclinicofcartagenacolombia
AT violamaricela pilotstudyofhemoglobinopathiesinnewbornsoftherafaelcalvomaternityclinicofcartagenacolombia
AT monerizcarlos pilotstudyofhemoglobinopathiesinnewbornsoftherafaelcalvomaternityclinicofcartagenacolombia
AT araqueluzmarina pilotstudyofhemoglobinopathiesinnewbornsoftherafaelcalvomaternityclinicofcartagenacolombia