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Development of Pyrazolone and Isoxazol-5-one Cambinol Analogues as Sirtuin Inhibitors

[Image: see text] Sirtuins are a family of NAD(+)-dependent protein deacetylases that play critical roles in epigenetic regulation, stress responses, and cellular aging in eukaryotic cells. In an effort to identify small molecule inhibitors of sirtuins for potential use as chemotherapeutics as well...

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Detalles Bibliográficos
Autores principales:	Mahajan, Sumit S., Scian, Michele, Sripathy, Smitha, Posakony, Jeff, Lao, Uyen, Loe, Taylor K., Leko, Vid, Thalhofer, Angel, Schuler, Aaron D., Bedalov, Antonio, Simon, Julian A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002067/ https://www.ncbi.nlm.nih.gov/pubmed/24697269 http://dx.doi.org/10.1021/jm4018064

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