Cargando…

Energy Landscapes and Catalysis in Nitric-oxide Synthase

Nitric oxide (NO) plays diverse roles in mammalian physiology. It is involved in blood pressure regulation, neurotransmission, and immune response, and is generated through complex electron transfer reactions catalyzed by NO synthases (NOS). In neuronal NOS (nNOS), protein domain dynamics and calmod...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sobolewska-Stawiarz, Anna, Leferink, Nicole G. H., Fisher, Karl, Heyes, Derren J., Hay, Sam, Rigby, Stephen E. J., Scrutton, Nigel S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2014
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002082/ https://www.ncbi.nlm.nih.gov/pubmed/24610812 http://dx.doi.org/10.1074/jbc.M114.548834

Ejemplares similares

A Conformational Sampling Model for Radical Catalysis in Pyridoxal Phosphate- and Cobalamin-dependent Enzymes
por: Menon, Binuraj R. K., et al.
Publicado: (2014)

Correlating Calmodulin Landscapes with Chemical Catalysis in Neuronal Nitric Oxide Synthase using Time-Resolved FRET and a 5-Deazaflavin Thermodynamic Trap
por: Hedison, Tobias M., et al.
Publicado: (2016)

Origin of the Proton-transfer Step in the Cofactor-free (1H)-3-Hydroxy-4-oxoquinaldine 2,4-Dioxygenase: EFFECT OF THE BASICITY OF AN ACTIVE SITE HIS RESIDUE
por: Hernandez-Ortega, Aitor, et al.
Publicado: (2014)

Decoding Catalysis by Terpene Synthases
por: Whitehead, Joshua N., et al.
Publicado: (2023)

The role of conserved residues in Fdc decarboxylase in prenylated flavin mononucleotide oxidative maturation, cofactor isomerization, and catalysis
por: Bailey, Samuel S., et al.
Publicado: (2018)

A Pivotal Role for Tryptophan 447 in Enzymatic Coupling of Human Endothelial Nitric Oxide Synthase (eNOS): EFFECTS ON TETRAHYDROBIOPTERIN-DEPENDENT CATALYSIS AND eNOS DIMERIZATION
por: Benson, Matthew A., et al.
Publicado: (2013)

Selective Irreversible Inhibition of Neuronal and Inducible Nitric-oxide Synthase in the Combined Presence of Hydrogen Sulfide and Nitric Oxide
por: Heine, Christian L., et al.
Publicado: (2015)

Epoxyqueuosine Reductase Structure Suggests a Mechanism for Cobalamin-dependent tRNA Modification
por: Payne, Karl A. P., et al.
Publicado: (2015)

Integrated Redox Sensor and Effector Functions for Tetrahydrobiopterin- and Glutathionylation-dependent Endothelial Nitric-oxide Synthase Uncoupling
por: Crabtree, Mark J., et al.
Publicado: (2013)

Engineering enzyme catalysis: an inverse approach
por: Megarity, Clare F.
Publicado: (2019)

Catalysis of non-canonical protein ubiquitylation by the ARIH1 ubiquitin ligase
por: Purser, Nicholas, et al.
Publicado: (2023)

Inverted stereocontrol of iridoid synthase in snapdragon
por: Kries, Hajo, et al.
Publicado: (2017)

Self-assembly Is Prerequisite for Catalysis of Fe(II) Oxidation by Catalytically Active Subunits of Ferritin
por: Ebrahimi, Kourosh Honarmand, et al.
Publicado: (2015)

Secreted heme peroxidase from Dictyostelium discoideum: Insights into catalysis, structure, and biological role
por: Nicolussi, Andrea, et al.
Publicado: (2018)

The ever-expanding limits of enzyme catalysis and biodegradation: polyaromatic, polychlorinated, polyfluorinated, and polymeric compounds
por: Wackett, Lawrence P., et al.
Publicado: (2020)

InhA, the enoyl-thioester reductase from Mycobacterium tuberculosis forms a covalent adduct during catalysis
por: Vögeli, Bastian, et al.
Publicado: (2018)

Structural analysis of group II chitinase (ChtII) catalysis completes the puzzle of chitin hydrolysis in insects
por: Chen, Wei, et al.
Publicado: (2018)

Does the pressure dependence of kinetic isotope effects report usefully on dynamics in enzyme H‐transfer reactions?
por: Hoeven, Robin, et al.
Publicado: (2015)

The Catalytic Architecture of Leukotriene C(4) Synthase with Two Arginine Residues
por: Saino, Hiromichi, et al.
Publicado: (2011)

Allosteric Activation of Trypanosomatid Deoxyhypusine Synthase by a Catalytically Dead Paralog
por: Nguyen, Suong, et al.
Publicado: (2013)

Nitroarachidonic Acid, a Novel Peroxidase Inhibitor of Prostaglandin Endoperoxide H Synthases 1 and 2
por: Trostchansky, Andrés, et al.
Publicado: (2011)

Molecular Characterization of a Novel Geranylgeranyl Pyrophosphate Synthase from Plasmodium Parasites
por: Artz, Jennifer D., et al.
Publicado: (2011)

Arginine 104 Is a Key Catalytic Residue in Leukotriene C(4) Synthase
por: Rinaldo-Matthis, Agnes, et al.
Publicado: (2010)

Insights into the catalysis of a lysine-tryptophan bond in bacterial peptides by a SPASM domain radical S-adenosylmethionine (SAM) peptide cyclase
por: Benjdia, Alhosna, et al.
Publicado: (2017)

Formation of Nitric Oxide by Aldehyde Dehydrogenase-2 Is Necessary and Sufficient for Vascular Bioactivation of Nitroglycerin
por: Opelt, Marissa, et al.
Publicado: (2016)

Identification of Key Residues Determining Species Differences in Inhibitor Binding of Microsomal Prostaglandin E Synthase-1
por: Pawelzik, Sven-Christian, et al.
Publicado: (2010)

Structural Basis of Catalysis in the Bacterial Monoterpene Synthases Linalool Synthase and 1,8-Cineole Synthase
por: Karuppiah, Vijaykumar, et al.
Publicado: (2017)

Structure and kinetics of indole-3-glycerol phosphate synthase from Pseudomonas aeruginosa: Decarboxylation is not essential for indole formation
por: Söderholm, Annika, et al.
Publicado: (2020)

A perspective on conformational control of electron transfer in nitric oxide synthases
por: Hedison, Tobias M., et al.
Publicado: (2017)

Unexpected Roles of a Tether Harboring a Tyrosine Gatekeeper Residue in Modular Nitrite Reductase Catalysis
por: Hedison, Tobias M., et al.
Publicado: (2019)

Structure and Mechanism of Human UDP-xylose Synthase: EVIDENCE FOR A PROMOTING ROLE OF SUGAR RING DISTORTION IN A THREE-STEP CATALYTIC CONVERSION OF UDP-GLUCURONIC ACID
por: Eixelsberger, Thomas, et al.
Publicado: (2012)

Ultrafast Vibrational Energy Transfer between Protein and Cofactor in a Flavoenzyme
por: Hardman, Samantha J. O., et al.
Publicado: (2020)

Catalytic Determinants of Alkene Production by the Cytochrome P450 Peroxygenase OleT(JE)
por: Matthews, Sarah, et al.
Publicado: (2017)

Allostery Wiring Map for Kinesin Energy Transduction and Its Evolution
por: Richard, Jessica, et al.
Publicado: (2016)

Predictive Engineering of Class I Terpene Synthases Using Experimental and Computational Approaches
por: Leferink, Nicole G. H., et al.
Publicado: (2021)

Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1
por: Chenge, Jude T., et al.
Publicado: (2017)

Identifying Natural Substrates for Dipeptidyl Peptidases 8 and 9 Using Terminal Amine Isotopic Labeling of Substrates (TAILS) Reveals in Vivo Roles in Cellular Homeostasis and Energy Metabolism
por: Wilson, Claire H., et al.
Publicado: (2013)

Cytochrome b Mutation Y268S Conferring Atovaquone Resistance Phenotype in Malaria Parasite Results in Reduced Parasite bc(1) Catalytic Turnover and Protein Expression
por: Fisher, Nicholas, et al.
Publicado: (2012)

Ligand-bound Structures and Site-directed Mutagenesis Identify the Acceptor and Secondary Binding Sites of Streptomyces coelicolor Maltosyltransferase GlgE
por: Syson, Karl, et al.
Publicado: (2016)

Oxidative cyclization of N-methyl-dopa by a fungal flavoenzyme of the amine oxidase family
por: Lahham, Majd, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_lpctpde19677h5q0ur27fcc70t