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Anti-amyloid Compounds Inhibit α-Synuclein Aggregation Induced by Protein Misfolding Cyclic Amplification (PMCA)

Filaments made of α-synuclein form the characteristic Lewy pathology in Parkinson and other diseases. The formation of α-synuclein filaments can be reproduced in vitro by incubation of recombinant protein, but the filament growth is very slow and highly variable and so unsuitable for fast high throu...

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Detalles Bibliográficos
Autores principales:	Herva, Maria Eugenia, Zibaee, Shahin, Fraser, Graham, Barker, Roger A., Goedert, Michel, Spillantini, Maria Grazia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2014
Materias:	Neurobiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002097/ https://www.ncbi.nlm.nih.gov/pubmed/24584936 http://dx.doi.org/10.1074/jbc.M113.542340

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