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Novel HLA Class I Alleles Associated with Indian Leprosy Patients

Convincing results on HLA Class II associations have been reported, however data on HLA class I association are limited and inconsistent from studies in Leprosy. We present here the HLA A, B, and C allele distribution by molecular high resolution PCR-SSOP technique in 32 leprosy patients compared wi...

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Detalles Bibliográficos
Autores principales: Shankarkumar, U., Ghosh, K., Badakere, S., Mohanty, D.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC400212/
https://www.ncbi.nlm.nih.gov/pubmed/12975536
http://dx.doi.org/10.1155/S1110724303210019
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author Shankarkumar, U.
Ghosh, K.
Badakere, S.
Mohanty, D.
author_facet Shankarkumar, U.
Ghosh, K.
Badakere, S.
Mohanty, D.
author_sort Shankarkumar, U.
collection PubMed
description Convincing results on HLA Class II associations have been reported, however data on HLA class I association are limited and inconsistent from studies in Leprosy. We present here the HLA A, B, and C allele distribution by molecular high resolution PCR-SSOP technique in 32 leprosy patients compared with the 67 controls, from the same ethnic background. The significant results from the present study were a significant increase in frequency of HLA A*0206, A*1102, B*4016, B*5110, Cw*0407, and Cw*0703 was observed when compared to controls. A striking decrease in the frequency of HLA A*0101, Cw*04011, and Cw*0602 leprosy patients was observed when compared to the controls. Further haplotype A*1102-B*4006-Cw*1502 was significantly increased among the lepromatous leprosy patients when compared to the controls. It seems that HLA class I alleles play vital roles in disease association/pathogenesis with leprosy among Indians.
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spelling pubmed-4002122004-08-03 Novel HLA Class I Alleles Associated with Indian Leprosy Patients Shankarkumar, U. Ghosh, K. Badakere, S. Mohanty, D. J Biomed Biotechnol Research Article Convincing results on HLA Class II associations have been reported, however data on HLA class I association are limited and inconsistent from studies in Leprosy. We present here the HLA A, B, and C allele distribution by molecular high resolution PCR-SSOP technique in 32 leprosy patients compared with the 67 controls, from the same ethnic background. The significant results from the present study were a significant increase in frequency of HLA A*0206, A*1102, B*4016, B*5110, Cw*0407, and Cw*0703 was observed when compared to controls. A striking decrease in the frequency of HLA A*0101, Cw*04011, and Cw*0602 leprosy patients was observed when compared to the controls. Further haplotype A*1102-B*4006-Cw*1502 was significantly increased among the lepromatous leprosy patients when compared to the controls. It seems that HLA class I alleles play vital roles in disease association/pathogenesis with leprosy among Indians. Hindawi Publishing Corporation 2003-08-20 /pmc/articles/PMC400212/ /pubmed/12975536 http://dx.doi.org/10.1155/S1110724303210019 Text en Copyright © 2003, Hindawi Publishing Corporation
spellingShingle Research Article
Shankarkumar, U.
Ghosh, K.
Badakere, S.
Mohanty, D.
Novel HLA Class I Alleles Associated with Indian Leprosy Patients
title Novel HLA Class I Alleles Associated with Indian Leprosy Patients
title_full Novel HLA Class I Alleles Associated with Indian Leprosy Patients
title_fullStr Novel HLA Class I Alleles Associated with Indian Leprosy Patients
title_full_unstemmed Novel HLA Class I Alleles Associated with Indian Leprosy Patients
title_short Novel HLA Class I Alleles Associated with Indian Leprosy Patients
title_sort novel hla class i alleles associated with indian leprosy patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC400212/
https://www.ncbi.nlm.nih.gov/pubmed/12975536
http://dx.doi.org/10.1155/S1110724303210019
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