ACE2 deficiency increases NADPH‐mediated oxidative stress in the kidney

Angiotensin‐converting enzyme 2 (ACE2) is highly expressed in the kidney and hydrolyzes angiotensin II (Ang II) to Ang(1–7). Since Ang II is a strong activator of oxidative stress, we reasoned that ACE2 could be involved in the regulation of renal oxidative stress by governing the levels of Ang II....

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Detalles Bibliográficos
Autores principales: Wysocki, Jan, Ortiz‐Melo, David I., Mattocks, Natalie K., Xu, Katherine, Prescott, Jessica, Evora, Karla, Ye, Minghao, Sparks, Matthew A., Haque, Syed K., Batlle, Daniel, Gurley, Susan B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002244/
https://www.ncbi.nlm.nih.gov/pubmed/24760518
http://dx.doi.org/10.1002/phy2.264

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