The Arabidopsis DDB1 interacting protein WDR55 is required for vegetative development

The CULLIN family of E3 ubiquitin ligases are important regulators of plant development and function. A newly identified class of CULLIN4-RING-E3 ligases (CRL4s) interacts with substrate receptors referred to as DDB1-CUL4 ASSOCIATED FACTORS (DCAFs) via a DDB1 linker protein. We have previously repor...

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Detalles Bibliográficos
Autores principales: Bjerkan, Katrine N, Grini, Paul E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002586/
https://www.ncbi.nlm.nih.gov/pubmed/23803743
http://dx.doi.org/10.4161/psb.25347
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author Bjerkan, Katrine N
Grini, Paul E
author_facet Bjerkan, Katrine N
Grini, Paul E
author_sort Bjerkan, Katrine N
collection PubMed
description The CULLIN family of E3 ubiquitin ligases are important regulators of plant development and function. A newly identified class of CULLIN4-RING-E3 ligases (CRL4s) interacts with substrate receptors referred to as DDB1-CUL4 ASSOCIATED FACTORS (DCAFs) via a DDB1 linker protein. We have previously reported that the WD40 protein WDR55 interacts with DDB1A and is thus a putative DCAF. Mutants of WDR55 are embryo lethal, suggesting that a DDB1(WDR55) complex could regulate embryo and endosperm development. Here we report that a weak allele homozygous for wdr55 display pleiotropic phenotypes in the seedling and adult stages, suggesting a novel regulatory role for WDR55 in vegetative development.
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spelling pubmed-40025862014-04-30 The Arabidopsis DDB1 interacting protein WDR55 is required for vegetative development Bjerkan, Katrine N Grini, Paul E Plant Signal Behav Research Paper The CULLIN family of E3 ubiquitin ligases are important regulators of plant development and function. A newly identified class of CULLIN4-RING-E3 ligases (CRL4s) interacts with substrate receptors referred to as DDB1-CUL4 ASSOCIATED FACTORS (DCAFs) via a DDB1 linker protein. We have previously reported that the WD40 protein WDR55 interacts with DDB1A and is thus a putative DCAF. Mutants of WDR55 are embryo lethal, suggesting that a DDB1(WDR55) complex could regulate embryo and endosperm development. Here we report that a weak allele homozygous for wdr55 display pleiotropic phenotypes in the seedling and adult stages, suggesting a novel regulatory role for WDR55 in vegetative development. Landes Bioscience 2013-09-01 2013-06-18 /pmc/articles/PMC4002586/ /pubmed/23803743 http://dx.doi.org/10.4161/psb.25347 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Research Paper
Bjerkan, Katrine N
Grini, Paul E
The Arabidopsis DDB1 interacting protein WDR55 is required for vegetative development
title The Arabidopsis DDB1 interacting protein WDR55 is required for vegetative development
title_full The Arabidopsis DDB1 interacting protein WDR55 is required for vegetative development
title_fullStr The Arabidopsis DDB1 interacting protein WDR55 is required for vegetative development
title_full_unstemmed The Arabidopsis DDB1 interacting protein WDR55 is required for vegetative development
title_short The Arabidopsis DDB1 interacting protein WDR55 is required for vegetative development
title_sort arabidopsis ddb1 interacting protein wdr55 is required for vegetative development
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002586/
https://www.ncbi.nlm.nih.gov/pubmed/23803743
http://dx.doi.org/10.4161/psb.25347
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