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Immunogenicity of therapeutic proteins: Influence of aggregation

The elicitation of anti-drug antibodies (ADA) against biotherapeutics can have detrimental effects on drug safety, efficacy, and pharmacokinetics. The immunogenicity of biotherapeutics is, therefore, an important issue. There is evidence that protein aggregation can result in enhanced immunogenicity...

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Detalles Bibliográficos
Autores principales:	Ratanji, Kirsty D., Derrick, Jeremy P., Dearman, Rebecca J., Kimber, Ian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Informa Healthcare USA, Inc. 2014
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002659/ https://www.ncbi.nlm.nih.gov/pubmed/23919460 http://dx.doi.org/10.3109/1547691X.2013.821564

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