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Hierarchical clustering of ryanodine receptors enables emergence of a calcium clock in sinoatrial node cells

The sinoatrial node, whose cells (sinoatrial node cells [SANCs]) generate rhythmic action potentials, is the primary pacemaker of the heart. During diastole, calcium released from the sarcoplasmic reticulum (SR) via ryanodine receptors (RyRs) interacts with membrane currents to control the rate of t...

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Detalles Bibliográficos
Autores principales:	Stern, Michael D., Maltseva, Larissa A., Juhaszova, Magdalena, Sollott, Steven J., Lakatta, Edward G., Maltsev, Victor A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2014
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003189/ https://www.ncbi.nlm.nih.gov/pubmed/24778430 http://dx.doi.org/10.1085/jgp.201311123

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