PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

PINK1 kinase activates the E3 ubiquitin ligase Parkin to induce selective autophagy of damaged mitochondria. However, it has been unclear how PINK1 activates and recruits Parkin to mitochondria. Although PINK1 phosphorylates Parkin, other PINK1 substrates appear to activate Parkin, as the mutation o...

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Detalles Bibliográficos
Autores principales: Kane, Lesley A., Lazarou, Michael, Fogel, Adam I., Li, Yan, Yamano, Koji, Sarraf, Shireen A., Banerjee, Soojay, Youle, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003245/
https://www.ncbi.nlm.nih.gov/pubmed/24751536
http://dx.doi.org/10.1083/jcb.201402104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003245/
https://www.ncbi.nlm.nih.gov/pubmed/24751536
http://dx.doi.org/10.1083/jcb.201402104

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