ATR checkpoint kinase and CRL1(βTRCP) collaborate to degrade ASF1a and thus repress genes overlapping with clusters of stalled replication forks

Many agents used for chemotherapy, such as doxorubicin, interfere with DNA replication, but the effect of this interference on transcription is largely unknown. Here we show that doxorubicin induces the firing of dense clusters of neoreplication origins that lead to clusters of stalled replication f...

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Detalles Bibliográficos
Autores principales: Im, Jun-Sub, Keaton, Mignon, Lee, Kyung Yong, Kumar, Pankaj, Park, Jonghoon, Dutta, Anindya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003279/
https://www.ncbi.nlm.nih.gov/pubmed/24700029
http://dx.doi.org/10.1101/gad.239194.114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003279/
https://www.ncbi.nlm.nih.gov/pubmed/24700029
http://dx.doi.org/10.1101/gad.239194.114

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