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ATR checkpoint kinase and CRL1(βTRCP) collaborate to degrade ASF1a and thus repress genes overlapping with clusters of stalled replication forks
Many agents used for chemotherapy, such as doxorubicin, interfere with DNA replication, but the effect of this interference on transcription is largely unknown. Here we show that doxorubicin induces the firing of dense clusters of neoreplication origins that lead to clusters of stalled replication f...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003279/ https://www.ncbi.nlm.nih.gov/pubmed/24700029 http://dx.doi.org/10.1101/gad.239194.114 |