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Distinct regulatory mechanisms balance DegP proteolysis to maintain cellular fitness during heat stress
Intracellular proteases combat proteotoxic stress by degrading damaged proteins, but their activity must be carefully controlled to maintain cellular fitness. The activity of Escherichia coli DegP, a highly conserved periplasmic protease, is regulated by substrate-dependent allosteric transformation...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003281/ https://www.ncbi.nlm.nih.gov/pubmed/24736846 http://dx.doi.org/10.1101/gad.238394.114 |