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Impact of amino acid substitutions in the V2 and C2 regions of human immunodeficiency virus type 1 CRF01_AE envelope glycoprotein gp120 on viral neutralization susceptibility to broadly neutralizing antibodies specific for the CD4 binding site

BACKGROUND: The CD4 binding site (CD4bs) of envelope glycoprotein (Env) gp120 is a functionally conserved, important target of anti-human immunodeficiency virus type 1 (HIV-1) neutralizing antibodies. Two neutralizing human monoclonal antibodies, IgG1 b12 (b12) and VRC01, are broadly reactive neutra...

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Detalles Bibliográficos
Autores principales:	Utachee, Piraporn, Isarangkura-na-ayuthaya, Panasda, Tokunaga, Kenzo, Ikuta, Kazuyoshi, Takeda, Naokazu, Kameoka, Masanori
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003292/ https://www.ncbi.nlm.nih.gov/pubmed/24758333 http://dx.doi.org/10.1186/1742-4690-11-32

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