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The duck genome and transcriptome provide insight into an avian influenza virus reservoir species
The duck (Anas platyrhynchos) is one of the principal natural hosts of influenza A viruses. We present the duck genome sequence and perform deep transcriptome analyses to investigate immune-related genes. Our data indicate that the duck possesses a contractive immune gene repertoire, as in chicken a...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003391/ https://www.ncbi.nlm.nih.gov/pubmed/23749191 http://dx.doi.org/10.1038/ng.2657 |
| _version_ | 1782313842015993856 |
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| author | Huang, Yinhua Li, Yingrui Burt, David W Chen, Hualan Zhang, Yong Qian, Wubin Kim, Heebal Gan, Shangquan Zhao, Yiqiang Li, Jianwen Yi, Kang Feng, Huapeng Zhu, Pengyang Li, Bo Liu, Qiuyue Fairley, Suan Magor, Katharine E Du, Zhenlin Hu, Xiaoxiang Goodman, Laurie Tafer, Hakim Vignal, Alain Lee, Taeheon Kim, Kyu-Won Sheng, Zheya An, Yang Searle, Steve Herrero, Javier Groenen, Martien A M Crooijmans, Richard P M A Faraut, Thomas Cai, Qingle Webster, Robert G Aldridge, Jerry R Warren, Wesley C Bartschat, Sebastian Kehr, Stephanie Marz, Manja Stadler, Peter F Smith, Jacqueline Kraus, Robert H S Zhao, Yaofeng Ren, Liming Fei, Jing Morisson, Mireille Kaiser, Pete Griffin, Darren K Rao, Man Pitel, Frederique Wang, Jun Li, Ning |
| author_facet | Huang, Yinhua Li, Yingrui Burt, David W Chen, Hualan Zhang, Yong Qian, Wubin Kim, Heebal Gan, Shangquan Zhao, Yiqiang Li, Jianwen Yi, Kang Feng, Huapeng Zhu, Pengyang Li, Bo Liu, Qiuyue Fairley, Suan Magor, Katharine E Du, Zhenlin Hu, Xiaoxiang Goodman, Laurie Tafer, Hakim Vignal, Alain Lee, Taeheon Kim, Kyu-Won Sheng, Zheya An, Yang Searle, Steve Herrero, Javier Groenen, Martien A M Crooijmans, Richard P M A Faraut, Thomas Cai, Qingle Webster, Robert G Aldridge, Jerry R Warren, Wesley C Bartschat, Sebastian Kehr, Stephanie Marz, Manja Stadler, Peter F Smith, Jacqueline Kraus, Robert H S Zhao, Yaofeng Ren, Liming Fei, Jing Morisson, Mireille Kaiser, Pete Griffin, Darren K Rao, Man Pitel, Frederique Wang, Jun Li, Ning |
| author_sort | Huang, Yinhua |
| collection | PubMed |
| description | The duck (Anas platyrhynchos) is one of the principal natural hosts of influenza A viruses. We present the duck genome sequence and perform deep transcriptome analyses to investigate immune-related genes. Our data indicate that the duck possesses a contractive immune gene repertoire, as in chicken and zebra finch, and this repertoire has been shaped through lineage-specific duplications. We identify genes that are responsive to influenza A viruses using the lung transcriptomes of control ducks and ones that were infected with either a highly pathogenic (A/duck/Hubei/49/05) or a weakly pathogenic (A/goose/Hubei/65/05) H5N1 virus. Further, we show how the duck’s defense mechanisms against influenza infection have been optimized through the diversification of its β-defensin and butyrophilin-like repertoires. These analyses, in combination with the genomic and transcriptomic data, provide a resource for characterizing the interaction between host and influenza viruses. |
| format | Online Article Text |
| id | pubmed-4003391 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-40033912014-04-29 The duck genome and transcriptome provide insight into an avian influenza virus reservoir species Huang, Yinhua Li, Yingrui Burt, David W Chen, Hualan Zhang, Yong Qian, Wubin Kim, Heebal Gan, Shangquan Zhao, Yiqiang Li, Jianwen Yi, Kang Feng, Huapeng Zhu, Pengyang Li, Bo Liu, Qiuyue Fairley, Suan Magor, Katharine E Du, Zhenlin Hu, Xiaoxiang Goodman, Laurie Tafer, Hakim Vignal, Alain Lee, Taeheon Kim, Kyu-Won Sheng, Zheya An, Yang Searle, Steve Herrero, Javier Groenen, Martien A M Crooijmans, Richard P M A Faraut, Thomas Cai, Qingle Webster, Robert G Aldridge, Jerry R Warren, Wesley C Bartschat, Sebastian Kehr, Stephanie Marz, Manja Stadler, Peter F Smith, Jacqueline Kraus, Robert H S Zhao, Yaofeng Ren, Liming Fei, Jing Morisson, Mireille Kaiser, Pete Griffin, Darren K Rao, Man Pitel, Frederique Wang, Jun Li, Ning Nat Genet Article The duck (Anas platyrhynchos) is one of the principal natural hosts of influenza A viruses. We present the duck genome sequence and perform deep transcriptome analyses to investigate immune-related genes. Our data indicate that the duck possesses a contractive immune gene repertoire, as in chicken and zebra finch, and this repertoire has been shaped through lineage-specific duplications. We identify genes that are responsive to influenza A viruses using the lung transcriptomes of control ducks and ones that were infected with either a highly pathogenic (A/duck/Hubei/49/05) or a weakly pathogenic (A/goose/Hubei/65/05) H5N1 virus. Further, we show how the duck’s defense mechanisms against influenza infection have been optimized through the diversification of its β-defensin and butyrophilin-like repertoires. These analyses, in combination with the genomic and transcriptomic data, provide a resource for characterizing the interaction between host and influenza viruses. 2013-06-09 2013-07 /pmc/articles/PMC4003391/ /pubmed/23749191 http://dx.doi.org/10.1038/ng.2657 Text en © 2013 Nature America, Inc. All rights reserved. This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
| spellingShingle | Article Huang, Yinhua Li, Yingrui Burt, David W Chen, Hualan Zhang, Yong Qian, Wubin Kim, Heebal Gan, Shangquan Zhao, Yiqiang Li, Jianwen Yi, Kang Feng, Huapeng Zhu, Pengyang Li, Bo Liu, Qiuyue Fairley, Suan Magor, Katharine E Du, Zhenlin Hu, Xiaoxiang Goodman, Laurie Tafer, Hakim Vignal, Alain Lee, Taeheon Kim, Kyu-Won Sheng, Zheya An, Yang Searle, Steve Herrero, Javier Groenen, Martien A M Crooijmans, Richard P M A Faraut, Thomas Cai, Qingle Webster, Robert G Aldridge, Jerry R Warren, Wesley C Bartschat, Sebastian Kehr, Stephanie Marz, Manja Stadler, Peter F Smith, Jacqueline Kraus, Robert H S Zhao, Yaofeng Ren, Liming Fei, Jing Morisson, Mireille Kaiser, Pete Griffin, Darren K Rao, Man Pitel, Frederique Wang, Jun Li, Ning The duck genome and transcriptome provide insight into an avian influenza virus reservoir species |
| title | The duck genome and transcriptome provide insight into an avian influenza virus reservoir species |
| title_full | The duck genome and transcriptome provide insight into an avian influenza virus reservoir species |
| title_fullStr | The duck genome and transcriptome provide insight into an avian influenza virus reservoir species |
| title_full_unstemmed | The duck genome and transcriptome provide insight into an avian influenza virus reservoir species |
| title_short | The duck genome and transcriptome provide insight into an avian influenza virus reservoir species |
| title_sort | duck genome and transcriptome provide insight into an avian influenza virus reservoir species |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003391/ https://www.ncbi.nlm.nih.gov/pubmed/23749191 http://dx.doi.org/10.1038/ng.2657 |
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