The emerging role of Twist proteins in hematopoietic cells and hematological malignancies

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Twist1 and Twist2 (Twist1–2) are two transcription factors, members of the basic helix-loop-helix family, that have been well established as master transcriptional regulators of embryogenesis and developmental programs of mesenchymal cell lineages. Their role in oncogenesis in epithelium-derived can...

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Autores principales: Merindol, N, Riquet, A, Szablewski, V, Eliaou, J-F, Puisieux, A, Bonnefoy, N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003416/
https://www.ncbi.nlm.nih.gov/pubmed/24769647
http://dx.doi.org/10.1038/bcj.2014.22
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author Merindol, N
Riquet, A
Szablewski, V
Eliaou, J-F
Puisieux, A
Bonnefoy, N
author_facet Merindol, N
Riquet, A
Szablewski, V
Eliaou, J-F
Puisieux, A
Bonnefoy, N
author_sort Merindol, N
collection PubMed
description Twist1 and Twist2 (Twist1–2) are two transcription factors, members of the basic helix-loop-helix family, that have been well established as master transcriptional regulators of embryogenesis and developmental programs of mesenchymal cell lineages. Their role in oncogenesis in epithelium-derived cancer and in epithelial-to-mesenchymal transition has also been thoroughly characterized. Recently, emerging evidence also suggests a key role for Twist1–2 in the function and development of hematopoietic cells, as well as in survival and development of numerous hematological malignancies. In this review, we summarize the latest data that depict the role of Twist1–2 in monocytes, T cells and B lymphocyte activation, and in associated hematological malignancies.
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spelling pubmed-40034162014-04-29 The emerging role of Twist proteins in hematopoietic cells and hematological malignancies Merindol, N Riquet, A Szablewski, V Eliaou, J-F Puisieux, A Bonnefoy, N Blood Cancer J Review Twist1 and Twist2 (Twist1–2) are two transcription factors, members of the basic helix-loop-helix family, that have been well established as master transcriptional regulators of embryogenesis and developmental programs of mesenchymal cell lineages. Their role in oncogenesis in epithelium-derived cancer and in epithelial-to-mesenchymal transition has also been thoroughly characterized. Recently, emerging evidence also suggests a key role for Twist1–2 in the function and development of hematopoietic cells, as well as in survival and development of numerous hematological malignancies. In this review, we summarize the latest data that depict the role of Twist1–2 in monocytes, T cells and B lymphocyte activation, and in associated hematological malignancies. Nature Publishing Group 2014-04 2014-04-25 /pmc/articles/PMC4003416/ /pubmed/24769647 http://dx.doi.org/10.1038/bcj.2014.22 Text en Copyright © 2014 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Review
Merindol, N
Riquet, A
Szablewski, V
Eliaou, J-F
Puisieux, A
Bonnefoy, N
The emerging role of Twist proteins in hematopoietic cells and hematological malignancies
title The emerging role of Twist proteins in hematopoietic cells and hematological malignancies
title_full The emerging role of Twist proteins in hematopoietic cells and hematological malignancies
title_fullStr The emerging role of Twist proteins in hematopoietic cells and hematological malignancies
title_full_unstemmed The emerging role of Twist proteins in hematopoietic cells and hematological malignancies
title_short The emerging role of Twist proteins in hematopoietic cells and hematological malignancies
title_sort emerging role of twist proteins in hematopoietic cells and hematological malignancies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003416/
https://www.ncbi.nlm.nih.gov/pubmed/24769647
http://dx.doi.org/10.1038/bcj.2014.22
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