Cargando…

Mechanism of reaction of chlorite with mammalian heme peroxidases

This study demonstrates that heme peroxidases from different superfamilies react differently with chlorite. In contrast to plant peroxidases, like horseradish peroxidase (HRP), the mammalian counterparts myeloperoxidase (MPO) and lactoperoxidase (LPO) are rapidly and irreversibly inactivated by chlo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jakopitsch, Christa, Pirker, Katharina F., Flemmig, Jörg, Hofbauer, Stefan, Schlorke, Denise, Furtmüller, Paul G., Arnhold, Jürgen, Obinger, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003552/ https://www.ncbi.nlm.nih.gov/pubmed/24632343 http://dx.doi.org/10.1016/j.jinorgbio.2014.02.010

Ejemplares similares

Transiently Produced Hypochlorite Is Responsible for the Irreversible Inhibition of Chlorite Dismutase
por: Hofbauer, Stefan, et al.
Publicado: (2014)

Chlorite dismutases – a heme enzyme family for use in bioremediation and generation of molecular oxygen
por: Hofbauer, Stefan, et al.
Publicado: (2014)

Independent evolution of four heme peroxidase superfamilies
por: Zámocký, Marcel, et al.
Publicado: (2015)

Structure and heme-binding properties of HemQ (chlorite dismutase-like protein) from Listeria monocytogenes
por: Hofbauer, Stefan, et al.
Publicado: (2015)

Manipulating Conserved Heme Cavity Residues of Chlorite Dismutase: Effect on Structure, Redox Chemistry, and Reactivity
por: Hofbauer, Stefan, et al.
Publicado: (2013)

Arresting the Catalytic Arginine in Chlorite Dismutases: Impact on Heme Coordination, Thermal Stability, and Catalysis
por: Schmidt, Daniel, et al.
Publicado: (2021)

Halogenation Activity of Mammalian Heme Peroxidases
por: Arnhold, Jürgen, et al.
Publicado: (2022)

From chlorite dismutase towards HemQ–the role of the proximal H-bonding network in haeme binding
por: Hofbauer, Stefan, et al.
Publicado: (2016)

Enhancing hypothiocyanite production by lactoperoxidase – mechanism and chemical properties of promotors
por: Gau, Jana, et al.
Publicado: (2015)

Dimeric chlorite dismutase from the nitrogen‐fixing cyanobacterium C yanothece sp. PCC7425
por: Schaffner, Irene, et al.
Publicado: (2015)

Turning points in the evolution of peroxidase–catalase superfamily: molecular phylogeny of hybrid heme peroxidases
por: Zámocký, Marcel, et al.
Publicado: (2014)

Redox Thermodynamics of High-Spin and Low-Spin Forms of Chlorite Dismutases with Diverse Subunit and Oligomeric Structures
por: Hofbauer, Stefan, et al.
Publicado: (2012)

Impact of subunit and oligomeric structure on the thermal and conformational stability of chlorite dismutases
por: Hofbauer, Stefan, et al.
Publicado: (2012)

Heme Peroxidases at Unperturbed and Inflamed Mucous Surfaces
por: Arnhold, Jürgen
Publicado: (2021)

Interaction with the Redox Cofactor MYW and Functional Role of a Mobile Arginine in Eukaryotic Catalase-Peroxidase
por: Gasselhuber, Bernhard, et al.
Publicado: (2016)

Investigation of Ion Binding in Chlorite Dismutases by Means of Molecular Dynamics Simulations
por: Sündermann, Axel, et al.
Publicado: (2014)

Compound I Formation and Reactivity in Dimeric Chlorite Dismutase: Impact of pH and the Dynamics of the Catalytic Arginine
por: Schmidt, Daniel, et al.
Publicado: (2023)

Fungal Hybrid B heme peroxidases – unique fusions of a heme peroxidase domain with a carbohydrate-binding domain
por: Zámocký, Marcel, et al.
Publicado: (2017)

Molecular Mechanism of Enzymatic Chlorite Detoxification: Insights from Structural and Kinetic Studies
por: Schaffner, Irene, et al.
Publicado: (2017)

Common Reactivity and Properties of Heme Peroxidases: A DFT Study of Their Origin
por: Ramos, Daniel R., et al.
Publicado: (2023)

Reaction intermediate rotation during the decarboxylation of coproheme to heme b in C. diphtheriae
por: Sebastiani, Federico, et al.
Publicado: (2021)

Molecular Evolution, Structure, and Function of Peroxidasins
por: Soudi, Monika, et al.
Publicado: (2012)

Posttranslational modification and heme cavity architecture of human eosinophil peroxidase—insights from first crystal structure and biochemical characterization
por: Pfanzagl, Vera, et al.
Publicado: (2023)

Secreted heme peroxidase from Dictyostelium discoideum: Insights into catalysis, structure, and biological role
por: Nicolussi, Andrea, et al.
Publicado: (2018)

Long-Term Effects of (–)-Epigallocatechin Gallate (EGCG) on Pristane-Induced Arthritis (PIA) in Female Dark Agouti Rats
por: Leichsenring, Anna, et al.
Publicado: (2016)

Unexpected photosensitivity of the well-characterized heme enzyme chlorite dismutase
por: Mahor, Durga, et al.
Publicado: (2020)

Unique Biradical Intermediate in the Mechanism of the Heme Enzyme Chlorite Dismutase
por: Püschmann, Julia, et al.
Publicado: (2021)

Myeloperoxidase scavenges peroxynitrite: A novel anti-inflammatory action of the heme enzyme
por: Koyani, Chintan N., et al.
Publicado: (2015)

The phylogeny of the mammalian heme peroxidases and the evolution of their diverse functions
por: Loughran, Noeleen B, et al.
Publicado: (2008)

Chemistry and Molecular Dynamics Simulations of Heme b-HemQ and Coproheme-HemQ
por: Hofbauer, Stefan, et al.
Publicado: (2016)

Agaricus meleagris pyranose dehydrogenase: Influence of covalent FAD linkage on catalysis and stability
por: Krondorfer, Iris, et al.
Publicado: (2014)

Roles of distal aspartate and arginine of B-class dye-decolorizing peroxidase in heterolytic hydrogen peroxide cleavage
por: Pfanzagl, Vera, et al.
Publicado: (2018)

Hydrogen peroxide‐mediated conversion of coproheme to heme b by HemQ—lessons from the first crystal structure and kinetic studies
por: Hofbauer, Stefan, et al.
Publicado: (2016)

Functional aspects of the interaction between interleukin-8 and sulfated glycosaminoglycans
por: Pichert, Annelie, et al.
Publicado: (2012)

Redox Cofactor Rotates during Its Stepwise Decarboxylation: Molecular Mechanism of Conversion of Coproheme to Heme b
por: Milazzo, Lisa, et al.
Publicado: (2019)

Structural aspects of enzymes involved in prokaryotic Gram-positive heme biosynthesis
por: Falb, Nikolaus, et al.
Publicado: (2023)

In Vitro Heme Coordination of a Dye-Decolorizing Peroxidase—The Interplay of Key Amino Acids, pH, Buffer and Glycerol
por: Nys, Kevin, et al.
Publicado: (2021)

Crystal structures and calorimetry reveal catalytically relevant binding mode of coproporphyrin and coproheme in coproporphyrin ferrochelatase
por: Hofbauer, Stefan, et al.
Publicado: (2019)

On the Track of Long-Range Electron Transfer in B-Type Dye-Decolorizing Peroxidases: Identification of a Tyrosyl Radical by Computational Prediction and Electron Paramagnetic Resonance Spectroscopy
por: Nys, Kevin, et al.
Publicado: (2021)

Understanding molecular enzymology of porphyrin-binding α + β barrel proteins - One fold, multiple functions
por: Hofbauer, Stefan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_fus8bmvo8k4p5bj4hn0arlaagv