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Diagnosis of snake envenomation using a simple phospholipase A(2) assay
Diagnosis of snake envenomation is challenging but critical for deciding on antivenom use. Phospholipase A(2) enzymes occur commonly in snake venoms and we hypothesized that phospholipase activity detected in human blood post-bite may be indicative of envenomation. Using a simple assay, potentially...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003729/ https://www.ncbi.nlm.nih.gov/pubmed/24777205 http://dx.doi.org/10.1038/srep04827 |
| Sumario: | Diagnosis of snake envenomation is challenging but critical for deciding on antivenom use. Phospholipase A(2) enzymes occur commonly in snake venoms and we hypothesized that phospholipase activity detected in human blood post-bite may be indicative of envenomation. Using a simple assay, potentially a bedside test, we detected high phospholipase activity in sera of patients with viper and elapid envenomation compared to minimal activity in non-envenomed patients. |
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