Diagnosis of snake envenomation using a simple phospholipase A(2) assay

Diagnosis of snake envenomation is challenging but critical for deciding on antivenom use. Phospholipase A(2) enzymes occur commonly in snake venoms and we hypothesized that phospholipase activity detected in human blood post-bite may be indicative of envenomation. Using a simple assay, potentially...

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Autores principales: Maduwage, Kalana, O'Leary, Margaret A., Isbister, Geoffrey K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003729/
https://www.ncbi.nlm.nih.gov/pubmed/24777205
http://dx.doi.org/10.1038/srep04827
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author Maduwage, Kalana
O'Leary, Margaret A.
Isbister, Geoffrey K.
author_facet Maduwage, Kalana
O'Leary, Margaret A.
Isbister, Geoffrey K.
author_sort Maduwage, Kalana
collection PubMed
description Diagnosis of snake envenomation is challenging but critical for deciding on antivenom use. Phospholipase A(2) enzymes occur commonly in snake venoms and we hypothesized that phospholipase activity detected in human blood post-bite may be indicative of envenomation. Using a simple assay, potentially a bedside test, we detected high phospholipase activity in sera of patients with viper and elapid envenomation compared to minimal activity in non-envenomed patients.
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spelling pubmed-40037292014-04-30 Diagnosis of snake envenomation using a simple phospholipase A(2) assay Maduwage, Kalana O'Leary, Margaret A. Isbister, Geoffrey K. Sci Rep Article Diagnosis of snake envenomation is challenging but critical for deciding on antivenom use. Phospholipase A(2) enzymes occur commonly in snake venoms and we hypothesized that phospholipase activity detected in human blood post-bite may be indicative of envenomation. Using a simple assay, potentially a bedside test, we detected high phospholipase activity in sera of patients with viper and elapid envenomation compared to minimal activity in non-envenomed patients. Nature Publishing Group 2014-04-29 /pmc/articles/PMC4003729/ /pubmed/24777205 http://dx.doi.org/10.1038/srep04827 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images in this article are included in the article's Creative Commons license, unless indicated otherwise in the image credit; if the image is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the image. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Article
Maduwage, Kalana
O'Leary, Margaret A.
Isbister, Geoffrey K.
Diagnosis of snake envenomation using a simple phospholipase A(2) assay
title Diagnosis of snake envenomation using a simple phospholipase A(2) assay
title_full Diagnosis of snake envenomation using a simple phospholipase A(2) assay
title_fullStr Diagnosis of snake envenomation using a simple phospholipase A(2) assay
title_full_unstemmed Diagnosis of snake envenomation using a simple phospholipase A(2) assay
title_short Diagnosis of snake envenomation using a simple phospholipase A(2) assay
title_sort diagnosis of snake envenomation using a simple phospholipase a(2) assay
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003729/
https://www.ncbi.nlm.nih.gov/pubmed/24777205
http://dx.doi.org/10.1038/srep04827
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