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Management of Cardiorenal Metabolic Syndrome in Diabetes Mellitus: A Phytotherapeutic Perspective

Cardiorenal syndrome (CRS) is a complex disease in which the heart and kidney are simultaneously affected and their deleterious declining functions are reinforced in a feedback cycle, with an accelerated progression. Although the coexistence of kidney and heart failure in the same individual carries...

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Autores principales: Song, Min Kyong, Davies, Neal M., Roufogalis, Basil D., Huang, Tom Hsun-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003752/
https://www.ncbi.nlm.nih.gov/pubmed/24818164
http://dx.doi.org/10.1155/2014/313718
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author Song, Min Kyong
Davies, Neal M.
Roufogalis, Basil D.
Huang, Tom Hsun-Wei
author_facet Song, Min Kyong
Davies, Neal M.
Roufogalis, Basil D.
Huang, Tom Hsun-Wei
author_sort Song, Min Kyong
collection PubMed
description Cardiorenal syndrome (CRS) is a complex disease in which the heart and kidney are simultaneously affected and their deleterious declining functions are reinforced in a feedback cycle, with an accelerated progression. Although the coexistence of kidney and heart failure in the same individual carries an extremely bad prognosis, the exact cause of deterioration and the pathophysiological mechanisms underlying the initiation and maintenance of the interaction are complex, multifactorial in nature, and poorly understood. Current therapy includes diuretics, natriuretic hormones, aquaretics (arginine vasopressin antagonists), vasodilators, and inotropes. However, large numbers of patients still develop intractable disease. Moreover, the development of resistance to many standard therapies, such as diuretics and inotropes, has led to an increasing movement toward utilization and development of novel therapies. Herbal and traditional natural medicines may complement or provide an alternative to prevent or delay the progression of CRS. This review provides an analysis of the possible mechanisms and the therapeutic potential of phytotherapeutic medicines for the amelioration of the progression of CRS.
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spelling pubmed-40037522014-05-11 Management of Cardiorenal Metabolic Syndrome in Diabetes Mellitus: A Phytotherapeutic Perspective Song, Min Kyong Davies, Neal M. Roufogalis, Basil D. Huang, Tom Hsun-Wei J Diabetes Res Review Article Cardiorenal syndrome (CRS) is a complex disease in which the heart and kidney are simultaneously affected and their deleterious declining functions are reinforced in a feedback cycle, with an accelerated progression. Although the coexistence of kidney and heart failure in the same individual carries an extremely bad prognosis, the exact cause of deterioration and the pathophysiological mechanisms underlying the initiation and maintenance of the interaction are complex, multifactorial in nature, and poorly understood. Current therapy includes diuretics, natriuretic hormones, aquaretics (arginine vasopressin antagonists), vasodilators, and inotropes. However, large numbers of patients still develop intractable disease. Moreover, the development of resistance to many standard therapies, such as diuretics and inotropes, has led to an increasing movement toward utilization and development of novel therapies. Herbal and traditional natural medicines may complement or provide an alternative to prevent or delay the progression of CRS. This review provides an analysis of the possible mechanisms and the therapeutic potential of phytotherapeutic medicines for the amelioration of the progression of CRS. Hindawi Publishing Corporation 2014 2014-04-13 /pmc/articles/PMC4003752/ /pubmed/24818164 http://dx.doi.org/10.1155/2014/313718 Text en Copyright © 2014 Min Kyong Song et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Song, Min Kyong
Davies, Neal M.
Roufogalis, Basil D.
Huang, Tom Hsun-Wei
Management of Cardiorenal Metabolic Syndrome in Diabetes Mellitus: A Phytotherapeutic Perspective
title Management of Cardiorenal Metabolic Syndrome in Diabetes Mellitus: A Phytotherapeutic Perspective
title_full Management of Cardiorenal Metabolic Syndrome in Diabetes Mellitus: A Phytotherapeutic Perspective
title_fullStr Management of Cardiorenal Metabolic Syndrome in Diabetes Mellitus: A Phytotherapeutic Perspective
title_full_unstemmed Management of Cardiorenal Metabolic Syndrome in Diabetes Mellitus: A Phytotherapeutic Perspective
title_short Management of Cardiorenal Metabolic Syndrome in Diabetes Mellitus: A Phytotherapeutic Perspective
title_sort management of cardiorenal metabolic syndrome in diabetes mellitus: a phytotherapeutic perspective
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003752/
https://www.ncbi.nlm.nih.gov/pubmed/24818164
http://dx.doi.org/10.1155/2014/313718
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