Cargando…
The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy
PAM4, a new monoclonal antibody (MAb) known as clivatuzumab, is highly reactive with pancreatic cancer and precursor lesions. It is absent from the normal tissues and has limited reactivity with nonpancreatic cancer. The detailed characteristic of the PAM4 epitope is unknown but recent studies have...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003775/ https://www.ncbi.nlm.nih.gov/pubmed/24818166 http://dx.doi.org/10.1155/2014/268479 |
_version_ | 1782313883963228160 |
---|---|
author | Han, Suxia Jin, Guihua Wang, Lijuan Li, Meng He, Chenchen Guo, Xijing Zhu, Qing |
author_facet | Han, Suxia Jin, Guihua Wang, Lijuan Li, Meng He, Chenchen Guo, Xijing Zhu, Qing |
author_sort | Han, Suxia |
collection | PubMed |
description | PAM4, a new monoclonal antibody (MAb) known as clivatuzumab, is highly reactive with pancreatic cancer and precursor lesions. It is absent from the normal tissues and has limited reactivity with nonpancreatic cancer. The detailed characteristic of the PAM4 epitope is unknown but recent studies have shown that it is dependent on MUC1 glycosylation status. The limited PAM4 expression pattern makes it an attractive candidate for management of pancreatic adenocarcinoma. In addition, PAM4 is a serum biomarker for diagnosis of pancreatic cancer. Several different radiolabeled immunodiagnostic and immunotherapeutic agents of PAM4 have been developed and some are being evaluated in preclinical and/or clinical studies. The review will focus on PAM4 and its potential utility for the diagnosis, radioimmunodetection, and radioimmunotherapy of pancreatic cancer. |
format | Online Article Text |
id | pubmed-4003775 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40037752014-05-11 The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy Han, Suxia Jin, Guihua Wang, Lijuan Li, Meng He, Chenchen Guo, Xijing Zhu, Qing J Immunol Res Review Article PAM4, a new monoclonal antibody (MAb) known as clivatuzumab, is highly reactive with pancreatic cancer and precursor lesions. It is absent from the normal tissues and has limited reactivity with nonpancreatic cancer. The detailed characteristic of the PAM4 epitope is unknown but recent studies have shown that it is dependent on MUC1 glycosylation status. The limited PAM4 expression pattern makes it an attractive candidate for management of pancreatic adenocarcinoma. In addition, PAM4 is a serum biomarker for diagnosis of pancreatic cancer. Several different radiolabeled immunodiagnostic and immunotherapeutic agents of PAM4 have been developed and some are being evaluated in preclinical and/or clinical studies. The review will focus on PAM4 and its potential utility for the diagnosis, radioimmunodetection, and radioimmunotherapy of pancreatic cancer. Hindawi Publishing Corporation 2014 2014-04-10 /pmc/articles/PMC4003775/ /pubmed/24818166 http://dx.doi.org/10.1155/2014/268479 Text en Copyright © 2014 Suxia Han et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Han, Suxia Jin, Guihua Wang, Lijuan Li, Meng He, Chenchen Guo, Xijing Zhu, Qing The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy |
title | The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy |
title_full | The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy |
title_fullStr | The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy |
title_full_unstemmed | The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy |
title_short | The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy |
title_sort | role of pam4 in the management of pancreatic cancer: diagnosis, radioimmunodetection, and radioimmunotherapy |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003775/ https://www.ncbi.nlm.nih.gov/pubmed/24818166 http://dx.doi.org/10.1155/2014/268479 |
work_keys_str_mv | AT hansuxia theroleofpam4inthemanagementofpancreaticcancerdiagnosisradioimmunodetectionandradioimmunotherapy AT jinguihua theroleofpam4inthemanagementofpancreaticcancerdiagnosisradioimmunodetectionandradioimmunotherapy AT wanglijuan theroleofpam4inthemanagementofpancreaticcancerdiagnosisradioimmunodetectionandradioimmunotherapy AT limeng theroleofpam4inthemanagementofpancreaticcancerdiagnosisradioimmunodetectionandradioimmunotherapy AT hechenchen theroleofpam4inthemanagementofpancreaticcancerdiagnosisradioimmunodetectionandradioimmunotherapy AT guoxijing theroleofpam4inthemanagementofpancreaticcancerdiagnosisradioimmunodetectionandradioimmunotherapy AT zhuqing theroleofpam4inthemanagementofpancreaticcancerdiagnosisradioimmunodetectionandradioimmunotherapy AT hansuxia roleofpam4inthemanagementofpancreaticcancerdiagnosisradioimmunodetectionandradioimmunotherapy AT jinguihua roleofpam4inthemanagementofpancreaticcancerdiagnosisradioimmunodetectionandradioimmunotherapy AT wanglijuan roleofpam4inthemanagementofpancreaticcancerdiagnosisradioimmunodetectionandradioimmunotherapy AT limeng roleofpam4inthemanagementofpancreaticcancerdiagnosisradioimmunodetectionandradioimmunotherapy AT hechenchen roleofpam4inthemanagementofpancreaticcancerdiagnosisradioimmunodetectionandradioimmunotherapy AT guoxijing roleofpam4inthemanagementofpancreaticcancerdiagnosisradioimmunodetectionandradioimmunotherapy AT zhuqing roleofpam4inthemanagementofpancreaticcancerdiagnosisradioimmunodetectionandradioimmunotherapy |