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The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy

PAM4, a new monoclonal antibody (MAb) known as clivatuzumab, is highly reactive with pancreatic cancer and precursor lesions. It is absent from the normal tissues and has limited reactivity with nonpancreatic cancer. The detailed characteristic of the PAM4 epitope is unknown but recent studies have...

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Detalles Bibliográficos
Autores principales: Han, Suxia, Jin, Guihua, Wang, Lijuan, Li, Meng, He, Chenchen, Guo, Xijing, Zhu, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003775/
https://www.ncbi.nlm.nih.gov/pubmed/24818166
http://dx.doi.org/10.1155/2014/268479
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author Han, Suxia
Jin, Guihua
Wang, Lijuan
Li, Meng
He, Chenchen
Guo, Xijing
Zhu, Qing
author_facet Han, Suxia
Jin, Guihua
Wang, Lijuan
Li, Meng
He, Chenchen
Guo, Xijing
Zhu, Qing
author_sort Han, Suxia
collection PubMed
description PAM4, a new monoclonal antibody (MAb) known as clivatuzumab, is highly reactive with pancreatic cancer and precursor lesions. It is absent from the normal tissues and has limited reactivity with nonpancreatic cancer. The detailed characteristic of the PAM4 epitope is unknown but recent studies have shown that it is dependent on MUC1 glycosylation status. The limited PAM4 expression pattern makes it an attractive candidate for management of pancreatic adenocarcinoma. In addition, PAM4 is a serum biomarker for diagnosis of pancreatic cancer. Several different radiolabeled immunodiagnostic and immunotherapeutic agents of PAM4 have been developed and some are being evaluated in preclinical and/or clinical studies. The review will focus on PAM4 and its potential utility for the diagnosis, radioimmunodetection, and radioimmunotherapy of pancreatic cancer.
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spelling pubmed-40037752014-05-11 The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy Han, Suxia Jin, Guihua Wang, Lijuan Li, Meng He, Chenchen Guo, Xijing Zhu, Qing J Immunol Res Review Article PAM4, a new monoclonal antibody (MAb) known as clivatuzumab, is highly reactive with pancreatic cancer and precursor lesions. It is absent from the normal tissues and has limited reactivity with nonpancreatic cancer. The detailed characteristic of the PAM4 epitope is unknown but recent studies have shown that it is dependent on MUC1 glycosylation status. The limited PAM4 expression pattern makes it an attractive candidate for management of pancreatic adenocarcinoma. In addition, PAM4 is a serum biomarker for diagnosis of pancreatic cancer. Several different radiolabeled immunodiagnostic and immunotherapeutic agents of PAM4 have been developed and some are being evaluated in preclinical and/or clinical studies. The review will focus on PAM4 and its potential utility for the diagnosis, radioimmunodetection, and radioimmunotherapy of pancreatic cancer. Hindawi Publishing Corporation 2014 2014-04-10 /pmc/articles/PMC4003775/ /pubmed/24818166 http://dx.doi.org/10.1155/2014/268479 Text en Copyright © 2014 Suxia Han et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Han, Suxia
Jin, Guihua
Wang, Lijuan
Li, Meng
He, Chenchen
Guo, Xijing
Zhu, Qing
The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy
title The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy
title_full The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy
title_fullStr The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy
title_full_unstemmed The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy
title_short The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy
title_sort role of pam4 in the management of pancreatic cancer: diagnosis, radioimmunodetection, and radioimmunotherapy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003775/
https://www.ncbi.nlm.nih.gov/pubmed/24818166
http://dx.doi.org/10.1155/2014/268479
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