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The Role of Androgen Hormones in Early Follicular Development

Background. Although chronic hyperandrogenism, a typical feature of polycystic ovary syndrome, is often associated with disturbed reproductive performance, androgens have been shown to promote ovarian follicle growth in shorter exposures. Here, we review the main effects of androgens on the regulati...

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Autores principales: Gervásio, Catiele Garcia, Bernuci, Marcelo Picinin, Silva-de-Sá, Marcos Felipe, Rosa-e-Silva, Ana Carolina Japur de Sá
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003798/
https://www.ncbi.nlm.nih.gov/pubmed/25006485
http://dx.doi.org/10.1155/2014/818010
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author Gervásio, Catiele Garcia
Bernuci, Marcelo Picinin
Silva-de-Sá, Marcos Felipe
Rosa-e-Silva, Ana Carolina Japur de Sá
author_facet Gervásio, Catiele Garcia
Bernuci, Marcelo Picinin
Silva-de-Sá, Marcos Felipe
Rosa-e-Silva, Ana Carolina Japur de Sá
author_sort Gervásio, Catiele Garcia
collection PubMed
description Background. Although chronic hyperandrogenism, a typical feature of polycystic ovary syndrome, is often associated with disturbed reproductive performance, androgens have been shown to promote ovarian follicle growth in shorter exposures. Here, we review the main effects of androgens on the regulation of early folliculogenesis and the potential of their application in improving follicular in vitro growth. Review. Androgens may affect folliculogenesis directly via androgen receptors (ARs) or indirectly through aromatization to estrogen. ARs are highly expressed in the granulosa and theca cells of early stage follicles and slightly expressed in mature follicles. Short-term androgen exposure augments FSH receptor expression in the granulosa cells of developing follicles and enhances the FSH-induced cAMP formation necessary for the transcription of genes involved in the control of follicular cell proliferation and differentiation. AR activation also increases insulin-like growth factor (IGF-1) and its receptor gene expression in the granulosa and theca cells of growing follicles and in the oocytes of primordial follicles, thus facilitating IGF-1 actions in both follicular recruitment and subsequent development. Conclusion. During the early and intermediate stages of follicular maturation, locally produced androgens facilitate the transition of follicles from the dormant to the growing pool as well as their further development.
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spelling pubmed-40037982014-07-08 The Role of Androgen Hormones in Early Follicular Development Gervásio, Catiele Garcia Bernuci, Marcelo Picinin Silva-de-Sá, Marcos Felipe Rosa-e-Silva, Ana Carolina Japur de Sá ISRN Obstet Gynecol Review Article Background. Although chronic hyperandrogenism, a typical feature of polycystic ovary syndrome, is often associated with disturbed reproductive performance, androgens have been shown to promote ovarian follicle growth in shorter exposures. Here, we review the main effects of androgens on the regulation of early folliculogenesis and the potential of their application in improving follicular in vitro growth. Review. Androgens may affect folliculogenesis directly via androgen receptors (ARs) or indirectly through aromatization to estrogen. ARs are highly expressed in the granulosa and theca cells of early stage follicles and slightly expressed in mature follicles. Short-term androgen exposure augments FSH receptor expression in the granulosa cells of developing follicles and enhances the FSH-induced cAMP formation necessary for the transcription of genes involved in the control of follicular cell proliferation and differentiation. AR activation also increases insulin-like growth factor (IGF-1) and its receptor gene expression in the granulosa and theca cells of growing follicles and in the oocytes of primordial follicles, thus facilitating IGF-1 actions in both follicular recruitment and subsequent development. Conclusion. During the early and intermediate stages of follicular maturation, locally produced androgens facilitate the transition of follicles from the dormant to the growing pool as well as their further development. Hindawi Publishing Corporation 2014-04-10 /pmc/articles/PMC4003798/ /pubmed/25006485 http://dx.doi.org/10.1155/2014/818010 Text en Copyright © 2014 Catiele Garcia Gervásio et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Gervásio, Catiele Garcia
Bernuci, Marcelo Picinin
Silva-de-Sá, Marcos Felipe
Rosa-e-Silva, Ana Carolina Japur de Sá
The Role of Androgen Hormones in Early Follicular Development
title The Role of Androgen Hormones in Early Follicular Development
title_full The Role of Androgen Hormones in Early Follicular Development
title_fullStr The Role of Androgen Hormones in Early Follicular Development
title_full_unstemmed The Role of Androgen Hormones in Early Follicular Development
title_short The Role of Androgen Hormones in Early Follicular Development
title_sort role of androgen hormones in early follicular development
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003798/
https://www.ncbi.nlm.nih.gov/pubmed/25006485
http://dx.doi.org/10.1155/2014/818010
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