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Trace Element Status (Iron, Zinc, Copper, Chromium, Cobalt, and Nickel) in Iron-Deficiency Anaemia of Children under 3 Years

Aim. To determine trace element status and aetiologic factors for development of trace elements deficiencies in children with iron-deficiency anaemia (IDA) aged 0 to 3 years. Contingent and Methods. 30 patients of the University Hospital, Pleven, Bulgaria—I group; 48 patients of the Sumy Regional Ch...

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Autores principales: Angelova, Maria Georgieva, Petkova-Marinova, Tsvetelina Valentinova, Pogorielov, Maksym Vladimirovich, Loboda, Andrii Nikolaevich, Nedkova-Kolarova, Vania Nedkova, Bozhinova, Atanaska Naumova
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003800/
https://www.ncbi.nlm.nih.gov/pubmed/24839556
http://dx.doi.org/10.1155/2014/718089
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author Angelova, Maria Georgieva
Petkova-Marinova, Tsvetelina Valentinova
Pogorielov, Maksym Vladimirovich
Loboda, Andrii Nikolaevich
Nedkova-Kolarova, Vania Nedkova
Bozhinova, Atanaska Naumova
author_facet Angelova, Maria Georgieva
Petkova-Marinova, Tsvetelina Valentinova
Pogorielov, Maksym Vladimirovich
Loboda, Andrii Nikolaevich
Nedkova-Kolarova, Vania Nedkova
Bozhinova, Atanaska Naumova
author_sort Angelova, Maria Georgieva
collection PubMed
description Aim. To determine trace element status and aetiologic factors for development of trace elements deficiencies in children with iron-deficiency anaemia (IDA) aged 0 to 3 years. Contingent and Methods. 30 patients of the University Hospital, Pleven, Bulgaria—I group; 48 patients of the Sumy Regional Child's Clinical Hospital, Sumy, Ukraine—II group; 25 healthy controls were investigated. Serum concentrations of iron, zinc, copper, chromium, cobalt, and nickel were determined spectrophotometrically and by atomic absorption spectrophotometry. Results. Because the obtained serum levels of zinc, copper, and chromium were near the lower reference limits, I group was divided into IA and IB. In IA group, serum concentrations were lower than the reference values for 47%, 57%, and 73% of patients, respectively. In IB group, these were within the reference values. In II group, results for zinc, cobalt, and nickel were significantly lower (P < 0.05), and results for copper were significantly higher in comparison to controls. Conclusion. Low serum concentrations of zinc, copper, cobalt, and nickel were mainly due to inadequate dietary intake, malabsorption, and micronutrient interactions in both studied groups. Increased serum copper in II group was probably due to metabolic changes resulting from adaptations in IDA. Data can be used for developing a diagnostic algorithm for IDA.
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spelling pubmed-40038002014-05-18 Trace Element Status (Iron, Zinc, Copper, Chromium, Cobalt, and Nickel) in Iron-Deficiency Anaemia of Children under 3 Years Angelova, Maria Georgieva Petkova-Marinova, Tsvetelina Valentinova Pogorielov, Maksym Vladimirovich Loboda, Andrii Nikolaevich Nedkova-Kolarova, Vania Nedkova Bozhinova, Atanaska Naumova Anemia Research Article Aim. To determine trace element status and aetiologic factors for development of trace elements deficiencies in children with iron-deficiency anaemia (IDA) aged 0 to 3 years. Contingent and Methods. 30 patients of the University Hospital, Pleven, Bulgaria—I group; 48 patients of the Sumy Regional Child's Clinical Hospital, Sumy, Ukraine—II group; 25 healthy controls were investigated. Serum concentrations of iron, zinc, copper, chromium, cobalt, and nickel were determined spectrophotometrically and by atomic absorption spectrophotometry. Results. Because the obtained serum levels of zinc, copper, and chromium were near the lower reference limits, I group was divided into IA and IB. In IA group, serum concentrations were lower than the reference values for 47%, 57%, and 73% of patients, respectively. In IB group, these were within the reference values. In II group, results for zinc, cobalt, and nickel were significantly lower (P < 0.05), and results for copper were significantly higher in comparison to controls. Conclusion. Low serum concentrations of zinc, copper, cobalt, and nickel were mainly due to inadequate dietary intake, malabsorption, and micronutrient interactions in both studied groups. Increased serum copper in II group was probably due to metabolic changes resulting from adaptations in IDA. Data can be used for developing a diagnostic algorithm for IDA. Hindawi Publishing Corporation 2014 2014-02-26 /pmc/articles/PMC4003800/ /pubmed/24839556 http://dx.doi.org/10.1155/2014/718089 Text en Copyright © 2014 Maria Georgieva Angelova et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Angelova, Maria Georgieva
Petkova-Marinova, Tsvetelina Valentinova
Pogorielov, Maksym Vladimirovich
Loboda, Andrii Nikolaevich
Nedkova-Kolarova, Vania Nedkova
Bozhinova, Atanaska Naumova
Trace Element Status (Iron, Zinc, Copper, Chromium, Cobalt, and Nickel) in Iron-Deficiency Anaemia of Children under 3 Years
title Trace Element Status (Iron, Zinc, Copper, Chromium, Cobalt, and Nickel) in Iron-Deficiency Anaemia of Children under 3 Years
title_full Trace Element Status (Iron, Zinc, Copper, Chromium, Cobalt, and Nickel) in Iron-Deficiency Anaemia of Children under 3 Years
title_fullStr Trace Element Status (Iron, Zinc, Copper, Chromium, Cobalt, and Nickel) in Iron-Deficiency Anaemia of Children under 3 Years
title_full_unstemmed Trace Element Status (Iron, Zinc, Copper, Chromium, Cobalt, and Nickel) in Iron-Deficiency Anaemia of Children under 3 Years
title_short Trace Element Status (Iron, Zinc, Copper, Chromium, Cobalt, and Nickel) in Iron-Deficiency Anaemia of Children under 3 Years
title_sort trace element status (iron, zinc, copper, chromium, cobalt, and nickel) in iron-deficiency anaemia of children under 3 years
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003800/
https://www.ncbi.nlm.nih.gov/pubmed/24839556
http://dx.doi.org/10.1155/2014/718089
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