Ziprasidone as Adjunctive Therapy in Severe Bipolar Patients Treated with Clozapine

Aim. To confirm the efficacy and tolerability of ziprasidone as adjunctive therapy in bipolar patients partially responding to clozapine or with persisting negative symptoms, overweight, or with metabolic syndrome. Methods. Eight patients with psychotic bipolar disorder were tested with the BPRS, th...

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Autores principales: Bartolommei, Natalia, Casamassima, Francesco, Pensabene, Laura, Luchini, Federica, Benvenuti, Antonella, Di Paolo, Antonello, Cosentino, Luca, Mauri, Mauro, Lattanzi, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003829/
https://www.ncbi.nlm.nih.gov/pubmed/25006524
http://dx.doi.org/10.1155/2014/904829
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author Bartolommei, Natalia
Casamassima, Francesco
Pensabene, Laura
Luchini, Federica
Benvenuti, Antonella
Di Paolo, Antonello
Cosentino, Luca
Mauri, Mauro
Lattanzi, Lorenzo
author_facet Bartolommei, Natalia
Casamassima, Francesco
Pensabene, Laura
Luchini, Federica
Benvenuti, Antonella
Di Paolo, Antonello
Cosentino, Luca
Mauri, Mauro
Lattanzi, Lorenzo
author_sort Bartolommei, Natalia
collection PubMed
description Aim. To confirm the efficacy and tolerability of ziprasidone as adjunctive therapy in bipolar patients partially responding to clozapine or with persisting negative symptoms, overweight, or with metabolic syndrome. Methods. Eight patients with psychotic bipolar disorder were tested with the BPRS, the HAM-D, and the CGI at T0 and retested after 2 weeks (T1). Plasma clozapine and norclozapine levels and BMI were tested at T0 and T1. Results. Ziprasidone was well tolerated by all the patients. BPRS and HAM-D scores were reduced in all patients. BMI was reduced in patients with a BMI at T0 higher than 25. Plasma levels of clozapine and norclozapine showed an irregular course.
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spelling pubmed-40038292014-07-08 Ziprasidone as Adjunctive Therapy in Severe Bipolar Patients Treated with Clozapine Bartolommei, Natalia Casamassima, Francesco Pensabene, Laura Luchini, Federica Benvenuti, Antonella Di Paolo, Antonello Cosentino, Luca Mauri, Mauro Lattanzi, Lorenzo ISRN Psychiatry Clinical Study Aim. To confirm the efficacy and tolerability of ziprasidone as adjunctive therapy in bipolar patients partially responding to clozapine or with persisting negative symptoms, overweight, or with metabolic syndrome. Methods. Eight patients with psychotic bipolar disorder were tested with the BPRS, the HAM-D, and the CGI at T0 and retested after 2 weeks (T1). Plasma clozapine and norclozapine levels and BMI were tested at T0 and T1. Results. Ziprasidone was well tolerated by all the patients. BPRS and HAM-D scores were reduced in all patients. BMI was reduced in patients with a BMI at T0 higher than 25. Plasma levels of clozapine and norclozapine showed an irregular course. Hindawi Publishing Corporation 2014-04-07 /pmc/articles/PMC4003829/ /pubmed/25006524 http://dx.doi.org/10.1155/2014/904829 Text en Copyright © 2014 Natalia Bartolommei et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Bartolommei, Natalia
Casamassima, Francesco
Pensabene, Laura
Luchini, Federica
Benvenuti, Antonella
Di Paolo, Antonello
Cosentino, Luca
Mauri, Mauro
Lattanzi, Lorenzo
Ziprasidone as Adjunctive Therapy in Severe Bipolar Patients Treated with Clozapine
title Ziprasidone as Adjunctive Therapy in Severe Bipolar Patients Treated with Clozapine
title_full Ziprasidone as Adjunctive Therapy in Severe Bipolar Patients Treated with Clozapine
title_fullStr Ziprasidone as Adjunctive Therapy in Severe Bipolar Patients Treated with Clozapine
title_full_unstemmed Ziprasidone as Adjunctive Therapy in Severe Bipolar Patients Treated with Clozapine
title_short Ziprasidone as Adjunctive Therapy in Severe Bipolar Patients Treated with Clozapine
title_sort ziprasidone as adjunctive therapy in severe bipolar patients treated with clozapine
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003829/
https://www.ncbi.nlm.nih.gov/pubmed/25006524
http://dx.doi.org/10.1155/2014/904829
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