Cargando…
Update on Salvage Options in Relapsed/Refractory Hodgkin Lymphoma after Autotransplant
Despite a high clinical success, relapse in Hodgkin lymphoma occurs in 10–30% of cases and 5–10% patients are nonresponsive to initial chemotherapy. The standard management of these patients includes high-dose chemotherapy followed by autologous stem cell transplant. However, 50% of patients ultimat...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003874/ https://www.ncbi.nlm.nih.gov/pubmed/25006506 http://dx.doi.org/10.1155/2014/605691 |
_version_ | 1782313902266122240 |
---|---|
author | Iqbal, Nida Kumar, Lalit Iqbal, Naveed |
author_facet | Iqbal, Nida Kumar, Lalit Iqbal, Naveed |
author_sort | Iqbal, Nida |
collection | PubMed |
description | Despite a high clinical success, relapse in Hodgkin lymphoma occurs in 10–30% of cases and 5–10% patients are nonresponsive to initial chemotherapy. The standard management of these patients includes high-dose chemotherapy followed by autologous stem cell transplant. However, 50% of patients ultimately relapse after autotransplant which poses a big challenge. Allogeneic stem cell transplantation offers the only chance of cure in these patients. For patients who are not candidates for allogeneic stem cell transplantation, achieving cure with other possible options is highly unlikely, and thus the treatment plan becomes noncurative. Various novel agents have shown promising results but the duration of response is short lived. A standard approach to deliver the most effective treatment for these patients is still lacking. This review focuses on the treatment options currently available for relapsed and refractory disease after autotransplant. |
format | Online Article Text |
id | pubmed-4003874 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40038742014-07-08 Update on Salvage Options in Relapsed/Refractory Hodgkin Lymphoma after Autotransplant Iqbal, Nida Kumar, Lalit Iqbal, Naveed ISRN Oncol Review Article Despite a high clinical success, relapse in Hodgkin lymphoma occurs in 10–30% of cases and 5–10% patients are nonresponsive to initial chemotherapy. The standard management of these patients includes high-dose chemotherapy followed by autologous stem cell transplant. However, 50% of patients ultimately relapse after autotransplant which poses a big challenge. Allogeneic stem cell transplantation offers the only chance of cure in these patients. For patients who are not candidates for allogeneic stem cell transplantation, achieving cure with other possible options is highly unlikely, and thus the treatment plan becomes noncurative. Various novel agents have shown promising results but the duration of response is short lived. A standard approach to deliver the most effective treatment for these patients is still lacking. This review focuses on the treatment options currently available for relapsed and refractory disease after autotransplant. Hindawi Publishing Corporation 2014-03-30 /pmc/articles/PMC4003874/ /pubmed/25006506 http://dx.doi.org/10.1155/2014/605691 Text en Copyright © 2014 Nida Iqbal et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Iqbal, Nida Kumar, Lalit Iqbal, Naveed Update on Salvage Options in Relapsed/Refractory Hodgkin Lymphoma after Autotransplant |
title | Update on Salvage Options in Relapsed/Refractory Hodgkin Lymphoma after Autotransplant |
title_full | Update on Salvage Options in Relapsed/Refractory Hodgkin Lymphoma after Autotransplant |
title_fullStr | Update on Salvage Options in Relapsed/Refractory Hodgkin Lymphoma after Autotransplant |
title_full_unstemmed | Update on Salvage Options in Relapsed/Refractory Hodgkin Lymphoma after Autotransplant |
title_short | Update on Salvage Options in Relapsed/Refractory Hodgkin Lymphoma after Autotransplant |
title_sort | update on salvage options in relapsed/refractory hodgkin lymphoma after autotransplant |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003874/ https://www.ncbi.nlm.nih.gov/pubmed/25006506 http://dx.doi.org/10.1155/2014/605691 |
work_keys_str_mv | AT iqbalnida updateonsalvageoptionsinrelapsedrefractoryhodgkinlymphomaafterautotransplant AT kumarlalit updateonsalvageoptionsinrelapsedrefractoryhodgkinlymphomaafterautotransplant AT iqbalnaveed updateonsalvageoptionsinrelapsedrefractoryhodgkinlymphomaafterautotransplant |